論文 - 詳細
| RRC ID | 59482 |
|---|---|
| 著者 | Dowen RH. |
| タイトル | CEH-60/PBX and UNC-62/MEIS Coordinate a Metabolic Switch that Supports Reproduction in C. elegans. |
| ジャーナル | Dev Cell |
| Abstract |
The molecular basis of how animals integrate metabolic, developmental, and environmental information before committing resources to reproduction is an unresolved issue in developmental biology. In C. elegans, adult animals reallocate fat stores from intestinal cells to the germline via low-density lipoprotein (LDL)-like particles to promote embryogenesis. Here, I demonstrate that two conserved homeodomain transcription factors, CEH-60/PBX and UNC-62/MEIS, coordinate a transcriptional network that supports reproduction while suppressing longevity and stress-response pathways. The CEH-60:UNC-62 heterodimer serves an unanticipated dual function in intestinal nuclei by directly activating the expression of lipoprotein genes while directly repressing stress-responsive genes. Consequently, ceh-60 mutants display fat storage defects, a dramatic lifespan extension, and hyper-activation of innate immunity genes. Finally, CEH-60 associates with PQM-1 at the DAF-16-associated element within the promoters of stress-responsive genes to control gene expression. Thus, CEH-60 governs an elaborate transcriptional network that balances stress responses and longevity against reproduction during developmental transitions. |
| 巻・号 | 49(2) |
| ページ | 235-250.e7 |
| 公開日 | 2019-4-22 |
| DOI | 10.1016/j.devcel.2019.03.002 |
| PII | S1534-5807(19)30179-0 |
| PMID | 30956009 |
| MeSH | Animals Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / metabolism* Caenorhabditis elegans Proteins / physiology Embryonic Development Gene Expression Regulation, Developmental / genetics Homeodomain Proteins / metabolism* Homeodomain Proteins / physiology Longevity / physiology Pre-B-Cell Leukemia Transcription Factor 1 / metabolism* Pre-B-Cell Leukemia Transcription Factor 1 / physiology Promoter Regions, Genetic / genetics Reproduction / physiology* Trans-Activators / metabolism Transcription Factors / metabolism* Transcription Factors / physiology Vitellogenesis / physiology |
| IF | 9.19 |
| 引用数 | 6 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm4063 |