論文 - 詳細
| RRC ID | 59540 |
|---|---|
| 著者 | Liu H, Qin LW, Li R, Zhang C, Al-Sheikh U, Wu ZX. |
| タイトル | Reciprocal modulation of 5-HT and octopamine regulates pumping via feedforward and feedback circuits in C. elegans. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Feeding is vital for animal survival and is tightly regulated by the endocrine and nervous systems. To study the mechanisms of humoral regulation of feeding behavior, we investigated serotonin (5-HT) and octopamine (OA) signaling in Caenorhabditis elegans, which uses pharyngeal pumping to ingest bacteria into the gut. We reveal that a cross-modulation mechanism between 5-HT and OA, which convey feeding and fasting signals, respectively, mainly functions in regulating the pumping and secretion of both neuromodulators via ADF/RIC/SIA feedforward neurocircuit (consisting of ADF, RIC, and SIA neurons) and ADF/RIC/AWB/ADF feedback neurocircuit (consisting of ADF, RIC, AWB, and ADF neurons) under conditions of food supply and food deprivation, respectively. Food supply stimulates food-sensing ADFs to release more 5-HT, which augments pumping via inhibiting OA secretion by RIC interneurons and, thus, alleviates pumping suppression by OA-activated SIA interneurons/motoneurons. In contrast, nutrient deprivation stimulates RICs to secrete OA, which suppresses pumping via activating SIAs and maintains basal pumping and 5-HT production activity through excitation of ADFs relayed by AWB sensory neurons. Notably, the feedforward and feedback circuits employ distinct modalities of neurosignal integration, namely, disinhibition and disexcitation, respectively. |
| 巻・号 | 116(14) |
| ページ | 7107-7112 |
| 公開日 | 2019-4-2 |
| DOI | 10.1073/pnas.1819261116 |
| PII | 1819261116 |
| PMID | 30872487 |
| PMC | PMC6452730 |
| MeSH | Animals Behavior, Animal / drug effects Behavior, Animal / physiology Caenorhabditis elegans / drug effects* Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / physiology Eating / physiology Fasting / physiology Feeding Behavior / drug effects* Feeding Behavior / physiology* Food Deprivation / physiology Interneurons / pathology Motor Neurons / physiology Octopamine / pharmacology* Sensory Receptor Cells / drug effects Serotonin / pharmacology* Signal Transduction / drug effects |
| IF | 9.58 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2146 |