Reference - Detail
| RRC ID | 59595 |
|---|---|
| Author | Shimizu T, Kato Y, Sakai Y, Hisamoto N, Matsumoto K. |
| Title | N-Glycosylation of the Discoidin Domain Receptor Is Required for Axon Regeneration in Caenorhabditis elegans. |
| Journal | Genetics |
| Abstract |
Axon regeneration following neuronal injury is an important repair mechanism that is not well understood at present. In Caenorhabditis elegans, axon regeneration is regulated by DDR-2, a receptor tyrosine kinase (RTK) that contains a discoidin domain and modulates the Met-like SVH-2 RTK-JNK MAP kinase signaling pathway. Here, we describe the svh-10/sqv-3 and svh-11 genes, which encode components of a conserved glycosylation pathway, and show that they modulate axon regeneration in C. elegans Overexpression of svh-2, but not of ddr-2, can suppress the axon regeneration defect observed in svh-11 mutants, suggesting that SVH-11 functions between DDR-2 and SVH-2 in this glycosylation pathway. Furthermore, we found that DDR-2 is N-glycosylated at the Asn-141 residue located in its discoidin domain, and mutation of this residue caused an axon regeneration defect. These findings indicate that N-linked glycosylation plays an important role in axon regeneration in C. elegans. |
| Volume | 213(2) |
| Pages | 491-500 |
| Published | 2019-10-1 |
| DOI | 10.1534/genetics.119.302492 |
| PII | genetics.119.302492 |
| PMID | 31371405 |
| PMC | PMC6781908 |
| MeSH | Animals Axons / metabolism Axons / physiology Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development Caenorhabditis elegans Proteins / genetics* Discoidin Domain Receptor 2 / genetics* Discoidin Domain Receptors / genetics Fucosyltransferases / genetics* Glycosylation MAP Kinase Signaling System / genetics Mutation Nerve Regeneration / genetics* Neurons / metabolism Receptor Protein-Tyrosine Kinases / genetics* |
| IF | 3.564 |
| Times Cited | 0 |
| Altmetric score |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 8 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm797 |