論文 - 詳細
| RRC ID | 59613 |
|---|---|
| 著者 | Torres Cleuren YN, Ewe CK, Chipman KC, Mears ER, Wood CG, Al-Alami CEA, Alcorn MR, Turner TL, Joshi PM, Snell RG, Rothman JH. |
| タイトル | Extensive intraspecies cryptic variation in an ancient embryonic gene regulatory network. |
| ジャーナル | Elife |
| Abstract |
Innovations in metazoan development arise from evolutionary modification of gene regulatory networks (GRNs). We report widespread cryptic variation in the requirement for two key regulatory inputs, SKN-1/Nrf2 and MOM-2/Wnt, into the C. elegans endoderm GRN. While some natural isolates show a nearly absolute requirement for these two regulators, in others, most embryos differentiate endoderm in their absence. GWAS and analysis of recombinant inbred lines reveal multiple genetic regions underlying this broad phenotypic variation. We observe a reciprocal trend, in which genomic variants, or knockdown of endoderm regulatory genes, that result in a high SKN-1 requirement often show low MOM-2/Wnt requirement and vice-versa, suggesting that cryptic variation in the endoderm GRN may be tuned by opposing requirements for these two key regulatory inputs. These findings reveal that while the downstream components in the endoderm GRN are common across metazoan phylogeny, initiating regulatory inputs are remarkably plastic even within a single species. |
| 巻・号 | 8 |
| 公開日 | 2019-8-15 |
| DOI | 10.7554/eLife.48220 |
| PII | 48220 |
| PMID | 31414984 |
| PMC | PMC6754231 |
| MeSH | Animals Caenorhabditis elegans / growth & development* Caenorhabditis elegans Proteins / biosynthesis* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism DNA-Binding Proteins / metabolism Gene Expression Regulation, Developmental* Gene Regulatory Networks* Genetic Variation Intracellular Signaling Peptides and Proteins / metabolism Progranulins / biosynthesis* Transcription Factors / metabolism Wnt Proteins / metabolism |
| IF | 7.551 |
| 引用数 | 4 |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 25 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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