論文 - 詳細
| RRC ID | 59622 |
|---|---|
| 著者 | Wolfe GS, Tong VW, Povse E, Merritt DM, Stegeman GW, Flibotte S, van der Kooy D. |
| タイトル | A Receptor Tyrosine Kinase Plays Separate Roles in Sensory Integration and Associative Learning in C. elegans. |
| ジャーナル | eNeuro |
| Abstract |
Associative learning and sensory integration are two behavioral processes that involve the sensation and processing of stimuli followed by an altered behavioral response to these stimuli, with learning requiring memory formation and retrieval. We found that the cellular and molecular actions of scd-2 dissociate sensory integration and associative learning. This was discovered through investigation of a Caenorhabditis elegans mutation (lrn-2 (mm99)) affecting both processes. After mapping and sequencing, lrn-2 was found to be allelic to the gene, scd-2scd-2-mediated associative learning and sensory integration operate in separate neurons as separate processes. We also find that memories can form from associations that are processed and stored independently from the integration of stimuli preceding an immediate behavioral decision. |
| 巻・号 | 6(4) |
| 公開日 | 2019-1-1 |
| DOI | 10.1523/ENEURO.0244-18.2019 |
| PII | ENEURO.0244-18.2019 |
| PMID | 31371455 |
| PMC | PMC6712205 |
| MeSH | Animals Association Learning / physiology* Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology* Mutation Neurons / physiology* Protein-Tyrosine Kinases / genetics Protein-Tyrosine Kinases / physiology* Sensation / physiology* |
| IF | 3.544 |
| 引用数 | 0 |
| リソース情報 | |
| 線虫 | tm3084 |