RRC ID 59987
Author Kimura Y, Higashijima SI.
Title Regulation of locomotor speed and selection of active sets of neurons by V1 neurons.
Journal Nat Commun
Abstract During fast movements in vertebrates, slow motor units are thought to be deactivated due to the mechanical demands of muscle contraction, but the associated neuronal mechanisms for this are unknown. Here, we perform functional analyses of spinal V1 neurons by selectively killing them in larval zebrafish, revealing two functions of V1 neurons. The first is the long-proposed role of V1 neurons: they play an important role in shortening the cycle period during swimming by providing in-phase inhibition. The second is that V1 neurons play an important role in the selection of active sets of neurons. We show that strong inhibitory inputs coming from V1 neurons play a crucial role in suppressing the activities of slow-type V2a and motor neurons, and, consequently, of slow muscles during fast swimming. Our results thus highlight the critical role of spinal inhibitory neurons for silencing slow-component neurons during fast movements.
Volume 10(1)
Pages 2268
Published 2019-5-22
DOI 10.1038/s41467-019-09871-x
PII 10.1038/s41467-019-09871-x
PMID 31118414
PMC PMC6531463
MeSH Animals Animals, Genetically Modified Anterior Horn Cells / physiology* Embryo, Nonmammalian Larva Models, Animal Renshaw Cells / physiology* Swimming / physiology* Zebrafish
IF 11.878
Times Cited 7
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