論文 - 詳細
| RRC ID | 59987 |
|---|---|
| 著者 | Kimura Y, Higashijima SI. |
| タイトル | Regulation of locomotor speed and selection of active sets of neurons by V1 neurons. |
| ジャーナル | Nat Commun |
| Abstract |
During fast movements in vertebrates, slow motor units are thought to be deactivated due to the mechanical demands of muscle contraction, but the associated neuronal mechanisms for this are unknown. Here, we perform functional analyses of spinal V1 neurons by selectively killing them in larval zebrafish, revealing two functions of V1 neurons. The first is the long-proposed role of V1 neurons: they play an important role in shortening the cycle period during swimming by providing in-phase inhibition. The second is that V1 neurons play an important role in the selection of active sets of neurons. We show that strong inhibitory inputs coming from V1 neurons play a crucial role in suppressing the activities of slow-type V2a and motor neurons, and, consequently, of slow muscles during fast swimming. Our results thus highlight the critical role of spinal inhibitory neurons for silencing slow-component neurons during fast movements. |
| 巻・号 | 10(1) |
| ページ | 2268 |
| 公開日 | 2019-5-22 |
| DOI | 10.1038/s41467-019-09871-x |
| PII | 10.1038/s41467-019-09871-x |
| PMID | 31118414 |
| PMC | PMC6531463 |
| MeSH | Animals Animals, Genetically Modified Anterior Horn Cells / physiology* Embryo, Nonmammalian Larva Models, Animal Renshaw Cells / physiology* Swimming / physiology* Zebrafish |
| IF | 11.878 |
| 引用数 | 7 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 17 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 7.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(eng1b:Gal4) Tg(eng1b:lRl-DTA) Tg(hoxa4a/9a:Cre) mnr2b-GFP |