RRC ID 59989
Author Menelaou E, McLean DL.
Title Hierarchical control of locomotion by distinct types of spinal V2a interneurons in zebrafish.
Journal Nat Commun
Abstract In all vertebrates, excitatory spinal interneurons execute dynamic adjustments in the timing and amplitude of locomotor movements. Currently, it is unclear whether interneurons responsible for timing control are distinct from those involved in amplitude control. Here, we show that in larval zebrafish, molecularly, morphologically and electrophysiologically distinct types of V2a neurons exhibit complementary patterns of connectivity. Stronger higher-order connections from type I neurons to other excitatory V2a and inhibitory V0d interneurons provide timing control, while stronger last-order connections from type II neurons to motor neurons provide amplitude control. Thus, timing and amplitude are coordinated by distinct interneurons distinguished not by their occupation of hierarchically-arranged anatomical layers, but rather by differences in the reliability and probability of higher-order and last-order connections that ultimately form a single anatomical layer. These findings contribute to our understanding of the origins of timing and amplitude control in the spinal cord.
Volume 10(1)
Pages 4197
Published 2019-9-13
DOI 10.1038/s41467-019-12240-3
PII 10.1038/s41467-019-12240-3
PMID 31519892
PMC PMC6744451
MeSH Animals Interneurons / cytology Interneurons / metabolism* Locomotion / physiology* Motor Neurons / cytology Motor Neurons / metabolism Spinal Cord / cytology Spinal Cord / metabolism Zebrafish
IF 11.878
Times Cited 5
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