| RRC ID |
60019
|
| 著者 |
Kobayashi Y, Shimazu T, Murata K, Itou T, Suzuki Y.
|
| タイトル |
An endogenous adeno-associated virus element in elephants.
|
| ジャーナル |
Virus Res
|
| Abstract |
An endogenous viral element derived from adeno-associated virus containing a nearly intact open reading frame (ORF) of the rep gene (enAAV-rep) has been identified in the genomes of various mammals including degu and African elephant. Particularly, in degu, mRNA expression of enAAV-rep has been observed specifically in the liver. Here we newly identified enAAV-rep in Asian elephant and rock hyrax, both of which are afrotherians. The enAAV-rep of African and Asian elephants appeared to be orthologous and originated from an integration event of the entire genome of AAV into the ancestral genome of elephants more than 6 million years ago, whereas that of rock hyrax appeared to have originated independently. Negative selection operating at the amino acid sequence level was detected for the ORF of enAAV-rep in elephants. As in degu, mRNA expression of enAAV-rep was specifically observed in the liver in Asian elephant. Integrations of enAAV-rep appeared to have occurred independently on the evolutionary lineages of elephants and degu, suggesting that the AAV Rep protein has been co-opted repeatedly in the mammalian liver.
|
| 巻・号 |
262
|
| ページ |
10-14
|
| 公開日 |
2019-3-1
|
| DOI |
10.1016/j.virusres.2018.04.015
|
| PII |
S0168-1702(18)30160-6
|
| PMID |
29702129
|
| MeSH |
Animals
Asia
Cell Line
DNA-Binding Proteins / genetics
Dependovirus / genetics*
Elephants / genetics
Elephants / virology*
Evolution, Molecular
Genome*
Liver / virology
Open Reading Frames / genetics
Phylogeny
Viral Proteins / genetics*
Virus Integration*
|
| IF |
2.736
|
| 引用数 |
2
|
| リソース情報 |
| ヒト・動物細胞 |
LACF-NaNaII(RCB2320) |
