RRC ID 60021
Author Brun NR, van Hage P, Hunting ER, Haramis AG, Vink SC, Vijver MG, Schaaf MJM, Tudorache C.
Title Polystyrene nanoplastics disrupt glucose metabolism and cortisol levels with a possible link to behavioural changes in larval zebrafish.
Journal Commun Biol
Abstract Plastic nanoparticles originating from weathering plastic waste are emerging contaminants in aquatic environments, with unknown modes of action in aquatic organisms. Recent studies suggest that internalised nanoplastics may disrupt processes related to energy metabolism. Such disruption can be crucial for organisms during development and may ultimately lead to changes in behaviour. Here, we investigated the link between polystyrene nanoplastic (PSNP)-induced signalling events and behavioural changes. Larval zebrafish exhibited PSNP accumulation in the pancreas, which coincided with a decreased glucose level. By using hyperglycemic and glucocorticoid receptor (Gr) mutant larvae, we demonstrate that the PSNP-induced disruption in glucose homoeostasis coincided with increased cortisol secretion and hyperactivity in challenge phases. Our work sheds new light on a potential mechanism underlying nanoplastics toxicity in fish, suggesting that the adverse effect of PSNPs are at least in part mediated by Gr activation in response to disrupted glucose homeostasis, ultimately leading to aberrant locomotor activity.
Volume 2
Pages 382
Published 2019
DOI 10.1038/s42003-019-0629-6
PII 629
PMID 31646185
PMC PMC6802380
MeSH Animals Animals, Genetically Modified Energy Metabolism / drug effects Glucose / metabolism Hydrocortisone / metabolism Larva / drug effects Larva / physiology Motor Activity / drug effects Mutation Nanoparticles / toxicity* Plastics / toxicity Polystyrenes / toxicity* Receptors, Glucocorticoid / genetics Receptors, Glucocorticoid / metabolism Tissue Distribution Water Pollutants, Chemical / toxicity* Zebrafish / genetics Zebrafish / physiology* Zebrafish Proteins / genetics Zebrafish Proteins / metabolism
Resource
Zebrafish s357