| RRC ID |
60039
|
| 著者 |
Navajas Acedo J, Voas MG, Alexander R, Woolley T, Unruh JR, Li H, Moens C, Piotrowski T.
|
| タイトル |
PCP and Wnt pathway components act in parallel during zebrafish mechanosensory hair cell orientation.
|
| ジャーナル |
Nat Commun
|
| Abstract |
Planar cell polarity (PCP) plays crucial roles in developmental processes such as gastrulation, neural tube closure and hearing. Wnt pathway mutants are often classified as PCP mutants due to similarities between their phenotypes. Here, we show that in the zebrafish lateral line, disruptions of the PCP and Wnt pathways have differential effects on hair cell orientations. While mutations in the PCP genes vangl2 and scrib cause random orientations of hair cells, mutations in wnt11f1, gpc4 and fzd7a/b induce hair cells to adopt a concentric pattern. This concentric pattern is not caused by defects in PCP but is due to misaligned support cells. The molecular basis of the support cell defect is unknown but we demonstrate that the PCP and Wnt pathways work in parallel to establish proper hair cell orientation. Consequently, hair cell orientation defects are not solely explained by defects in PCP signaling, and some hair cell phenotypes warrant re-evaluation.
|
| 巻・号 |
10(1)
|
| ページ |
3993
|
| 公開日 |
2019-9-5
|
| DOI |
10.1038/s41467-019-12005-y
|
| PII |
10.1038/s41467-019-12005-y
|
| PMID |
31488837
|
| PMC |
PMC6728366
|
| MeSH |
Animals
Cell Polarity / genetics*
Cell Polarity / physiology*
Gene Expression Regulation, Developmental
Hair Cells, Auditory / metabolism*
Heparan Sulfate Proteoglycans / genetics
Membrane Proteins / genetics
Morphogenesis / genetics
Morphogenesis / physiology
Mutation
Neural Tube Defects / genetics
Neurulation / genetics
Receptors, Cell Surface / genetics
Wnt Signaling Pathway / genetics*
Wnt Signaling Pathway / physiology*
Wnt1 Protein / genetics
Zebrafish / genetics*
Zebrafish Proteins / genetics
|
| IF |
11.878
|
| 引用数 |
4
|
| リソース情報 |
| ゼブラフィッシュ |
landlocked rw468 |
