RRC ID 60064
Author Antinucci P, Folgueira M, Bianco IH.
Title Pretectal neurons control hunting behaviour.
Journal Elife
Abstract For many species, hunting is an innate behaviour that is crucial for survival, yet the circuits that control predatory action sequences are poorly understood. We used larval zebrafish to identify a population of pretectal neurons that control hunting. By combining calcium imaging with a virtual hunting assay, we identified a discrete pretectal region that is selectively active when animals initiate hunting. Targeted genetic labelling allowed us to examine the function and morphology of individual cells and identify two classes of pretectal neuron that project to ipsilateral optic tectum or the contralateral tegmentum. Optogenetic stimulation of single neurons of either class was able to induce sustained hunting sequences, in the absence of prey. Furthermore, laser ablation of these neurons impaired prey-catching and prevented induction of hunting by optogenetic stimulation of the anterior-ventral tectum. We propose that this specific population of pretectal neurons functions as a command system to induce predatory behaviour.
Volume 8
Published 2019-10-8
DOI 10.7554/eLife.48114
PII 48114
PMID 31591961
PMC PMC6783268
MeSH Animals Brain Mapping Neural Pathways / anatomy & histology Neural Pathways / physiology Neurons / physiology* Optical Imaging Optogenetics Predatory Behavior* Pretectal Region / anatomy & histology Pretectal Region / physiology* Staining and Labeling Zebrafish
IF 7.551
Times Cited 4
Zebrafish Tg(vglut2a:lRl-GFP)