Reference - Detail
| RRC ID | 6038 |
|---|---|
| Author | Kiyotani K, Sakaguchi T, Kato A, Nagai Y, Yoshida T. |
| Title | Paramyxovirus Sendai virus V protein counteracts innate virus clearance through IRF-3 activation, but not via interferon, in mice. |
| Journal | Virology |
| Abstract |
The present study was undertaken to clarify the role of Sendai virus (SeV) V protein, which has been shown to downregulate IFN-beta induction through inhibition of IRF-3 activation, in viral pathogenesis. Mice infected with rSeV mutants, deficient in V expression or expressing V lacking the C-terminus, had several-fold higher IFN activity levels in the lungs than those in wild-type virus-infected mice, and the mutant viruses were rapidly excluded from the lung from the early phase of infection before induction of acquired immunity. In addition, the unique early clearance of the mutants did not occur in IRF-3 knockout (KO) mice. However, high titers of IFN were detected even in the infected KO mice. Furthermore, early clearance of the mutant viruses was also observed in IFN signaling-deficient mice, IFN-alpha/beta receptor KO mice and STAT1 KO mice. These results indicate that SeV V protein counteracts IRF-3-mediated innate antiviral immunity for efficient virus replication and pathogenesis in mice, but it is not IFN. |
| Volume | 359(1) |
| Pages | 82-91 |
| Published | 2007-3-1 |
| DOI | 10.1016/j.virol.2006.08.053 |
| PII | S0042-6822(06)00625-8 |
| PMID | 17027894 |
| MeSH | Animals Disease Models, Animal Female Immunity, Innate Interferon Regulatory Factor-3 / genetics Interferon Regulatory Factor-3 / metabolism* Interferon-beta / immunology Interferon-beta / metabolism Lung / immunology Lung / virology Male Mice Mice, Inbred C57BL Mice, Knockout Mutation Receptors, Interferon / genetics Receptors, Interferon / immunology Respirovirus Infections / immunology* Respirovirus Infections / virology* STAT1 Transcription Factor / genetics STAT1 Transcription Factor / immunology Sendai virus / immunology* Sendai virus / physiology* Sequence Deletion Signal Transduction Viral Proteins / genetics Viral Proteins / physiology* Virus Replication |
| IF | 2.819 |
| Times Cited | 21 |
| WOS Category | VIROLOGY |
| Resource | |
| Mice | RBRC00858 |