RRC ID 60951
Author Zhang M, Nagaosa K, Nakai Y, Yasugi T, Kushihiki M, Rahmatika D, Sato M, Shiratsuchi A, Nakanishi Y.
Title Role for phagocytosis in the prevention of neoplastic transformation in Drosophila.
Journal Genes Cells
Abstract Immunity is considered to be involved in the prevention of cancer. Although both humoral and cellular immune reactions may participate, underlying mechanisms have yet to be clarified. The present study was conducted to clarify this issue using a Drosophila model, in which neoplastic transformation was induced through the simultaneous inhibition of cell-cycle checkpoints and apoptosis. We first determined the location of hemocytes, blood cells of Drosophila playing a role of immune cells, in neoplasia-induced and normal larvae, but there was no significant difference between the two groups. When gene expression pattern in larval hemocytes was determined, the expression of immunity-related genes including those necessary for phagocytosis was reduced in the neoplasia model. We then asked the involvement of phagocytosis in the prevention of neoplasia examining animals where the expression of engulfment receptors instead of apoptosis was retarded. We found that the inhibition of engulfment receptor expression augmented the occurrence of neoplasia induced by a defect in cell-cycle checkpoints. This suggested a role for phagocytosis in the prevention of neoplastic transformation in Drosophila.
Volume 25(10)
Pages 675-684
Published 2020-10-1
DOI 10.1111/gtc.12804
PMID 32865275
MeSH Animals Apoptosis / immunology Cell Line Cell Transformation, Neoplastic / genetics Cell Transformation, Neoplastic / immunology* Cell Transformation, Neoplastic / metabolism* Drosophila melanogaster / genetics Drosophila melanogaster / immunology Drosophila melanogaster / metabolism Female Hemocytes / cytology Hemocytes / immunology Hemocytes / metabolism Larva / metabolism Male Neoplasms / genetics Neoplasms / immunology Phagocytosis / genetics Phagocytosis / immunology* Phagocytosis / physiology
IF 1.655
Resource
Drosophila 1762R-1