論文 - 詳細
| RRC ID | 61508 |
|---|---|
| 著者 | Katsumata K, Ikeda H, Sato M, Ishizu A, Kawarada Y, Kato H, Wakisaka A, Koike T, Yoshiki T. |
| タイトル | Cytokine regulation of env gene expression of human endogenous retrovirus-R in human vascular endothelial cells. |
| ジャーナル | Clin Immunol |
| Abstract |
To determine whether human endogenous retroviruses are implicated in the pathogenesis of inflammatory vascular diseases of unknown etiology, we examined mRNA expression of a human endogenous retrovirus, HERV-R, which has a long open reading frame in the env region, in cultured human vascular endothelial and smooth muscle cells stimulated in the presence of various cytokines. mRNA of HERV-R was always evident in these cells but not in fibroblastic cells. Levels of expression in vascular endothelial cells were significantly regulated by treatment with tumor necrosis factor-alpha, interleukin (IL)-1alpha, and IL-1beta as up-regulators and interferon-gamma as a down-regulator. These observations are interpreted to mean that HERV-R expression may be up- or down-regulated at sites of inflammation in vessels in vivo and hence may play a pathogenetic role in inflammatory vascular diseases in humans, perhaps similar to endogenous retroviruses in mouse models of polyarteritis nodosa in humans. |
| 巻・号 | 93(1) |
| ページ | 75-80 |
| 公開日 | 1999-10-1 |
| DOI | 10.1006/clim.1999.4762 |
| PII | S1521-6616(99)94762-9 |
| PMID | 10497013 |
| MeSH | Cells, Cultured Cytokines / pharmacology* Endothelium, Vascular / cytology* Endothelium, Vascular / metabolism Gene Expression Regulation / drug effects Genes, env / genetics* Humans Muscle, Smooth, Vascular / cytology RNA, Messenger / metabolism Retroviridae / genetics* Reverse Transcriptase Polymerase Chain Reaction |
| IF | 3.368 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | NB1RGB(RCB0222) HUC-F(RCB0153) |