論文 - 詳細
| RRC ID | 61604 |
|---|---|
| 著者 | Kakimoto T, Shiraishi R, Iwakiri R, Fujimoto K, Takahashi H, Hamajima H, Mizuta T, Ideguchi H, Toda S, Kitajima Y, Ozaki I, Matsuhashi S. |
| タイトル | Expression patterns of the tumor suppressor PDCD4 and correlation with β-catenin expression in gastric cancers. |
| ジャーナル | Oncol Rep |
| Abstract |
The expression patterns of PDCD4, a tumor suppressor, and β-catenin were immunohistologically investigated in gastric carcinoma tissues. In normal gastric tissues, PDCD4 was strongly expressed in the cell nuclei, but weakly expressed in the cytoplasm. In gastric adenocarcinoma tissues, nuclear PDCD4 expression was decreased, while cytoplasmic PDCD4 expression was unchanged or somewhat increased. In gastric signet ring cell carcinoma tissues, PDCD4 expression patterns were different from the expression patterns of the adenocarcinoma tissues, and PDCD4 was localized in the nuclei of the carcinoma cells as a belt in the middle of the epithelial layer. The nuclear localization of PDCD4 in the adenocarcinoma tissues was correlated with the membrane localization of β-catenin, the activation of which stimulates invasion of colon cancer cells. PDCD4 expression was correlated with β-catenin expression in gastric carcinoma cell lines, but not with E-cadherin, as the binding partner in the cell membrane. |
| 巻・号 | 26(6) |
| ページ | 1385-92 |
| 公開日 | 2011-12-1 |
| DOI | 10.3892/or.2011.1450 |
| PMID | 21894439 |
| MeSH | Adenocarcinoma / metabolism* Adenocarcinoma / pathology Aged Aged, 80 and over Apoptosis Regulatory Proteins / genetics Apoptosis Regulatory Proteins / metabolism* Cell Line, Tumor Cell Membrane / metabolism Cell Nucleus / metabolism Female Gene Expression* Gene Expression Regulation, Neoplastic Humans Male Middle Aged RNA-Binding Proteins / genetics RNA-Binding Proteins / metabolism* Stomach Neoplasms / metabolism* Stomach Neoplasms / pathology beta Catenin / genetics beta Catenin / metabolism* |
| IF | 3.417 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | MKN7(RCB0999) RCB0999(RCB1001) MKN74(RCB1002) MKN1(RCB1003) Kato III(RCB2088) |