RRC ID 62026
著者 Narimatsu S, Kobayashi N, Masubuchi Y, Horie T, Kakegawa T, Kobayashi H, Hardwick JP, Gonzalez FJ, Shimada N, Ohmori S, Kitada M, Asaoka K, Kataoka H, Yamamoto S, Satoh T.
タイトル Species difference in enantioselectivity for the oxidation of propranolol by cytochrome P450 2D enzymes.
ジャーナル Chem Biol Interact
Abstract We examined and compared enantioselectivity in the oxidation of propranolol (PL) by liver microsomes from humans and Japanese monkeys (Macaca fuscata). PL was oxidized at the naphthalene ring to 4-hydroxypropranolol, 5-hydroxypropranolol and side chain N-desisopropylpropranolol by human liver microsomes with enantioselectivity of [R(+)>S(-)] in PL oxidation rates at substrate concentrations of 10 microM and 1 mM. In contrast, reversed enantioselectivity [R(+)
巻・号 127(1)
ページ 73-90
公開日 2000-6-15
DOI 10.1016/s0009-2797(00)00174-5
PII S0009-2797(00)00174-5
PMID 10903420
MeSH Animals Baculoviridae / genetics Cytochrome P-450 CYP2D6 / genetics Cytochrome P-450 CYP2D6 / metabolism* Humans Hydroxylation Kinetics Macaca Microsomes, Liver / enzymology* Oxidation-Reduction Propranolol / chemistry* Propranolol / metabolism* Recombinant Proteins / metabolism Species Specificity Spodoptera / metabolism Stereoisomerism* Substrate Specificity Transfection
IF 3.723
リソース情報
ヒト・動物細胞 Sf9(RCB0563)