論文 - 詳細
| RRC ID | 62103 |
|---|---|
| 著者 | Zhang BN, Watanabe S, Kohyama M, Saijo K, Kusakabe M, Ohno T. |
| タイトル | Tumor formation suppressed in gammadeltaT knock-out mice. |
| ジャーナル | Cancer Lett |
| Abstract |
Tumor formation was examined in mice in which the beta-chain gene of alphabetaT was knocked out (alphabetaT-KO mice) or the delta-chain gene of gammadeltaT was knocked out (gammadeltaT-KO mice). Development of Hepa 1-6 cell hepatoma was observed in six of six alphabetaT-KO mice, in four of six wild-type mice, and in only one of six gammadeltaT-KO mice. These results imply that gammadeltaT cells play a role in suppression of killer cell activity in tumor-bearing mice. |
| 巻・号 | 153(1-2) |
| ページ | 63-6 |
| 公開日 | 2000-5-29 |
| DOI | 10.1016/s0304-3835(00)00343-8 |
| PII | S0304383500003438 |
| PMID | 10779631 |
| MeSH | Animals Carcinoma, Hepatocellular / genetics Carcinoma, Hepatocellular / immunology* Cell Transformation, Neoplastic / genetics Female Male Mice Mice, Inbred C57BL Mice, Knockout Neoplasm Transplantation Receptors, Antigen, T-Cell, gamma-delta / genetics Receptors, Antigen, T-Cell, gamma-delta / physiology* T-Lymphocytes / immunology T-Lymphocytes / physiology* Tumor Cells, Cultured |
| IF | 7.36 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | Hepa 1-6(RCB1638) |