論文 - 詳細
| RRC ID | 62238 |
|---|---|
| 著者 | Kuse Y, Ogawa K, Tsuruma K, Shimazawa M, Hara H. |
| タイトル | Damage of photoreceptor-derived cells in culture induced by light emitting diode-derived blue light. |
| ジャーナル | Sci Rep |
| Abstract |
Our eyes are increasingly exposed to light from the emitting diode (LED) light of video display terminals (VDT) which contain much blue light. VDTs are equipped with televisions, personal computers, and smart phones. The present study aims to clarify the mechanism underlying blue LED light-induced photoreceptor cell damage. Murine cone photoreceptor-derived cells (661 W) were exposed to blue, white, or green LED light (0.38 mW/cm(2)). In the present study, blue LED light increased reactive oxygen species (ROS) production, altered the protein expression level, induced the aggregation of short-wavelength opsins (S-opsin), resulting in severe cell damage. While, blue LED light damaged the primary retinal cells and the damage was photoreceptor specific. N-Acetylcysteine (NAC), an antioxidant, protected against the cellular damage induced by blue LED light. Overall, the LED light induced cell damage was wavelength-, but not energy-dependent and may cause more severe retinal photoreceptor cell damage than the other LED light. |
| 巻・号 | 4 |
| ページ | 5223 |
| 公開日 | 2014-6-9 |
| DOI | 10.1038/srep05223 |
| PII | srep05223 |
| PMID | 24909301 |
| PMC | PMC4048889 |
| MeSH | Animals Antioxidants / metabolism Apoptosis / physiology* Cells, Cultured Light / adverse effects* Mice Photoreceptor Cells, Vertebrate / metabolism Photoreceptor Cells, Vertebrate / pathology* Reactive Oxygen Species / metabolism Retina / metabolism Retina / pathology Rod Opsins / metabolism |
| IF | 3.998 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 130 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | NB1RGB(RCB0222) |