Reference - Detail
RRC ID | 6224 |
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Author | Wada H, Okamoto H. |
Title | Roles of planar cell polarity pathway genes for neural migration and differentiation. |
Journal | Dev Growth Differ |
Abstract |
Planar cell polarity (PCP) in epithelial cells is essential for the organization of tissues and their functions. The conserved non-canonical Wnt/PCP pathway regulates this process in both Drosophila and vertebrates. However, recent studies have revealed that a similar set of genes, which may not be related to PCP, regulates oriented cell movement during development. In the present review, recent findings on neural migration in zebrafish hindbrain and axonal guidance in mouse forebrain and spinal cord are discussed. Future analyses on defects in vertebrate PCP mutants will provide novel insights into the conserved and diverse roles of non-canonical Wnt/PCP pathway genes in vertebrate brain development. |
Volume | 51(3) |
Pages | 233-40 |
Published | 2009-4-1 |
DOI | 10.1111/j.1440-169X.2009.01092.x |
PII | DGD1092 |
PMID | 19298553 |
MeSH | Animals Cell Differentiation / genetics Cell Differentiation / physiology* Cell Movement / genetics Cell Movement / physiology* Cell Polarity / genetics Cell Polarity / physiology* Drosophila Mice Neurons / cytology* Neurons / metabolism* Prosencephalon / anatomy & histology Prosencephalon / cytology Prosencephalon / metabolism Signal Transduction Spinal Cord / anatomy & histology Spinal Cord / cytology Spinal Cord / metabolism Zebrafish |
IF | 1.723 |
Times Cited | 22 |
WOS Category | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
Resource | |
Zebrafish | Review |