| RRC ID |
6241
|
| 著者 |
Ma LH, Punnamoottil B, Rinkwitz S, Baker R.
|
| タイトル |
Mosaic hoxb4a neuronal pleiotropism in zebrafish caudal hindbrain.
|
| ジャーナル |
PLoS One
|
| Abstract |
To better understand how individual genes and experience influence behavior, the role of a single homeotic unit, hoxb4a, was comprehensively analyzed in vivo by clonal and retrograde fluorescent labeling of caudal hindbrain neurons in a zebrafish enhancer-trap YFP line. A quantitative spatiotemporal neuronal atlas showed hoxb4a activity to be highly variable and mosaic in rhombomere 7-8 reticular, motoneuronal and precerebellar nuclei with expression decreasing differentially in all subgroups through juvenile stages. The extensive Hox mosaicism and widespread pleiotropism demonstrate that the same transcriptional protein plays a role in the development of circuits that drive behaviors from autonomic through motor function including cerebellar regulation. We propose that the continuous presence of hoxb4a positive neurons may provide a developmental plasticity for behavior-specific circuits to accommodate experience- and growth-related changes. Hence, the ubiquitous hoxb4a pleitropism and modularity likely offer an adaptable transcriptional element for circuit modification during both growth and evolution.
|
| 巻・号 |
4(6)
|
| ページ |
e5944
|
| 公開日 |
2009-6-17
|
| DOI |
10.1371/journal.pone.0005944
|
| PMID |
19536294
|
| PMC |
PMC2693931
|
| MeSH |
Animals
Axons
Body Patterning
Fluorescent Dyes / pharmacology
Gene Expression Regulation
Homeodomain Proteins / metabolism*
In Situ Hybridization
Microscopy, Confocal
Neurons / metabolism
Rhombencephalon / metabolism*
Spinal Cord / metabolism
Spinal Cord / pathology
Transcription, Genetic
Zebrafish
Zebrafish Proteins / metabolism*
|
| IF |
2.74
|
| 引用数 |
19
|
|
WOS 分野
|
NEUROSCIENCES
|
| リソース情報 |
| ゼブラフィッシュ |
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