論文 - 詳細
| RRC ID | 6241 |
|---|---|
| 著者 | Ma LH, Punnamoottil B, Rinkwitz S, Baker R. |
| タイトル | Mosaic hoxb4a neuronal pleiotropism in zebrafish caudal hindbrain. |
| ジャーナル | PLoS One |
| Abstract |
To better understand how individual genes and experience influence behavior, the role of a single homeotic unit, hoxb4a, was comprehensively analyzed in vivo by clonal and retrograde fluorescent labeling of caudal hindbrain neurons in a zebrafish enhancer-trap YFP line. A quantitative spatiotemporal neuronal atlas showed hoxb4a activity to be highly variable and mosaic in rhombomere 7-8 reticular, motoneuronal and precerebellar nuclei with expression decreasing differentially in all subgroups through juvenile stages. The extensive Hox mosaicism and widespread pleiotropism demonstrate that the same transcriptional protein plays a role in the development of circuits that drive behaviors from autonomic through motor function including cerebellar regulation. We propose that the continuous presence of hoxb4a positive neurons may provide a developmental plasticity for behavior-specific circuits to accommodate experience- and growth-related changes. Hence, the ubiquitous hoxb4a pleitropism and modularity likely offer an adaptable transcriptional element for circuit modification during both growth and evolution. |
| 巻・号 | 4(6) |
| ページ | e5944 |
| 公開日 | 2009-6-17 |
| DOI | 10.1371/journal.pone.0005944 |
| PMID | 19536294 |
| PMC | PMC2693931 |
| MeSH | Animals Axons Body Patterning Fluorescent Dyes / pharmacology Gene Expression Regulation Homeodomain Proteins / metabolism* In Situ Hybridization Microscopy, Confocal Neurons / metabolism Rhombencephalon / metabolism* Spinal Cord / metabolism Spinal Cord / pathology Transcription, Genetic Zebrafish Zebrafish Proteins / metabolism* |
| IF | 2.74 |
| 引用数 | 19 |
| WOS 分野 | NEUROSCIENCES |
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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