Reference - Detail
| RRC ID | 6262 |
|---|---|
| Author | Vladar EK, Antic D, Axelrod JD. |
| Title | Planar cell polarity signaling: the developing cell's compass. |
| Journal | Cold Spring Harb Perspect Biol |
| Abstract |
Cells of many tissues acquire cellular asymmetry to execute their physiologic functions. The planar cell polarity system, first characterized in Drosophila, is important for many of these events. Studies in Drosophila suggest that an upstream system breaks cellular symmetry by converting tissue gradients to subcellular asymmetry, whereas a downstream system amplifies subcellular asymmetry and communicates polarity between cells. In this review, we discuss apparent similarities and differences in the mechanism that controls PCP as it has been adapted to a broad variety of morphological cellular asymmetries in various organisms. |
| Volume | 1(3) |
| Pages | a002964 |
| Published | 2009-9-1 |
| DOI | 10.1101/cshperspect.a002964 |
| PMID | 20066108 |
| PMC | PMC2773631 |
| MeSH | Animals Body Patterning Cell Division Cell Movement Cell Polarity* Cilia / metabolism Cytoskeleton / metabolism Developmental Biology / methods* Drosophila Humans Mice Models, Biological Models, Genetic Mutation Signal Transduction* |
| IF | 7.64 |
| Times Cited | 137 |
| WOS Category | CELL BIOLOGY |
| Resource | |
| Zebrafish | Review? |