Reference - Detail
|Author||Aoki S, Aboshi T, Shiono Y, Kimura KI, Murata T, Arai D, Iizuka Y, Murayama T.|
|Title||Constituents of the Fruiting Body of Poisonous Mushroom Omphalotus japonicus.|
|Journal||Chem Pharm Bull (Tokyo)|
Six new sesquiterpenes, tsukiyols A-C, neoilludin C, and 4-O-methylneoilludins A and B, were isolated from the fruiting body of Omphalotus japonicus (Kawam.) Kirchm. & O. K. Mill. Additionally, six known compounds, illudin S, neoilludins A-B, 5-hydroxydichomitol, ergosterolperoxide, and 3β,5α,9α-trihydroxyergosta-7,22-diene-6-one, were also obtained. Their chemical structures were determined with MS, IR, and NMR spectra and the absolute configurations of neoilludins A-C, 4-O-methylneoilludins A, and B were determined with electronic circular dichroism (ECD). Illudin S and 3β,5α,9α-trihydroxyergosta-7,22-diene-6-one showed cytotoxicity against human acute promyelocytic leukemia HL60 cells. Illudin S, 4-O-methylneoilludin A, B, and tsukiyol C showed growth-restoring activity against mutant yeast via Ca2+-signal transduction.
|MeSH||Agaricales / chemistry* Antifungal Agents / chemistry Antifungal Agents / isolation & purification Antifungal Agents / pharmacology* Antineoplastic Agents / chemistry Antineoplastic Agents / isolation & purification Antineoplastic Agents / pharmacology* Calcium Signaling / drug effects Cell Proliferation / drug effects Density Functional Theory Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Fruiting Bodies, Fungal / chemistry* HL-60 Cells Humans Microbial Sensitivity Tests Molecular Conformation Mutation Saccharomyces cerevisiae / drug effects* Saccharomyces cerevisiae / genetics Saccharomyces cerevisiae / metabolism Sesquiterpenes / chemistry Sesquiterpenes / isolation & purification Sesquiterpenes / pharmacology* Structure-Activity Relationship|
|Human and Animal Cells||HL60(RCB0041)|