論文 - 詳細
| RRC ID | 63016 |
|---|---|
| 著者 | Pandey A, Stawiski EW, Durinck S, Gowda H, Goldstein LD, Barbhuiya MA, Schröder MS, Sreenivasamurthy SK, Kim SW, Phalke S, Suryamohan K, Lee K, Chakraborty P, Kode V, Shi X, Chatterjee A, Datta K, Khan AA, Subbannayya T, Wang J, Chaudhuri S, Gupta S, Shrivastav BR, Jaiswal BS, Poojary SS, Bhunia S, Garcia P, Bizama C, Rosa L, Kwon W, Kim H, Han Y, Yadav TD, Ramprasad VL, Chaudhuri A, Modrusan Z, Roa JC, Tiwari PK, Jang JY, Seshagiri S. |
| タイトル | Integrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate. |
| ジャーナル | Nat Commun |
| Abstract |
Gallbladder cancer (GBC) is an aggressive gastrointestinal malignancy with no approved targeted therapy. Here, we analyze exomes (n = 160), transcriptomes (n = 115), and low pass whole genomes (n = 146) from 167 gallbladder cancers (GBCs) from patients in Korea, India and Chile. In addition, we also sequence samples from 39 GBC high-risk patients and detect evidence of early cancer-related genomic lesions. Among the several significantly mutated genes not previously linked to GBC are ETS domain genes ELF3 and EHF, CTNNB1, APC, NSD1, KAT8, STK11 and NFE2L2. A majority of ELF3 alterations are frame-shift mutations that result in several cancer-specific neoantigens that activate T-cells indicating that they are cancer vaccine candidates. In addition, we identify recurrent alterations in KEAP1/NFE2L2 and WNT pathway in GBC. Taken together, these define multiple targetable therapeutic interventions opportunities for GBC treatment and management. |
| 巻・号 | 11(1) |
| ページ | 4225 |
| 公開日 | 2020-8-24 |
| DOI | 10.1038/s41467-020-17880-4 |
| PII | 10.1038/s41467-020-17880-4 |
| PMID | 32839463 |
| PMC | PMC7445288 |
| MeSH | Cancer Vaccines / genetics Cancer Vaccines / immunology Chile DNA-Binding Proteins / genetics* DNA-Binding Proteins / immunology DNA-Binding Proteins / metabolism Frameshift Mutation* Gallbladder Neoplasms / diagnosis Gallbladder Neoplasms / genetics* Gallbladder Neoplasms / metabolism Gene Expression Profiling / methods Gene Expression Regulation, Neoplastic Genetic Predisposition to Disease / genetics* Genomics / methods Humans India Kelch-Like ECH-Associated Protein 1 / genetics Kelch-Like ECH-Associated Protein 1 / metabolism NF-E2-Related Factor 2 / genetics NF-E2-Related Factor 2 / metabolism Proto-Oncogene Proteins c-ets / genetics* Proto-Oncogene Proteins c-ets / immunology Proto-Oncogene Proteins c-ets / metabolism Republic of Korea Transcription Factors / genetics* Transcription Factors / immunology Transcription Factors / metabolism Wnt Signaling Pathway / genetics beta Catenin / genetics beta Catenin / metabolism |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 42 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | TGBC24TKB(RCB1196) TGBC2TKB(RCB1130) G-415(RCB2640) |