論文 - 詳細
| RRC ID | 63176 |
|---|---|
| 著者 | Matur M, Madhyastha H, Shruthi TS, Madhyastha R, Srinivas SP, Navya PN, Daima HK. |
| タイトル | Engineering bioactive surfaces on nanoparticles and their biological interactions. |
| ジャーナル | Sci Rep |
| Abstract |
The successful integration of nanoparticles into biomedical applications requires modulation of their surface properties so that the interaction with biological systems is regulated to minimize toxicity for biological function. In the present work, we have engineered bioactive surfaces on gold (Au) and silver (Ag) nanoparticles and subsequently evaluated their interaction with mouse skin fibroblasts and macrophages. The Au and Ag nanoparticles were synthesized using tyrosine, tryptophan, isonicotinylhydrazide, epigallocatechin gallate, and curcumin as reducing and stabilizing agents. The nanoparticles thus prepared showed surface corona and exhibited free radical scavenging and enzyme activities with limited cytotoxicity and genotoxicity. We have thus developed avenues for engineering the surface of nanoparticles for biological applications. |
| 巻・号 | 10(1) |
| ページ | 19713 |
| 公開日 | 2020-11-12 |
| DOI | 10.1038/s41598-020-75465-z |
| PII | 10.1038/s41598-020-75465-z |
| PMID | 33184324 |
| PMC | PMC7665184 |
| MeSH | Animals Cell Survival Cells, Cultured DNA Damage* Fibroblasts / cytology* Fibroblasts / drug effects Free Radical Scavengers / pharmacology* Gold / chemistry* Macrophages / cytology* Macrophages / drug effects Metal Nanoparticles / administration & dosage* Metal Nanoparticles / chemistry Mice Peroxidase / metabolism Silver / chemistry* Surface Properties |
| IF | 3.998 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |