| RRC ID |
63176
|
| 著者 |
Matur M, Madhyastha H, Shruthi TS, Madhyastha R, Srinivas SP, Navya PN, Daima HK.
|
| タイトル |
Engineering bioactive surfaces on nanoparticles and their biological interactions.
|
| ジャーナル |
Sci Rep
|
| Abstract |
The successful integration of nanoparticles into biomedical applications requires modulation of their surface properties so that the interaction with biological systems is regulated to minimize toxicity for biological function. In the present work, we have engineered bioactive surfaces on gold (Au) and silver (Ag) nanoparticles and subsequently evaluated their interaction with mouse skin fibroblasts and macrophages. The Au and Ag nanoparticles were synthesized using tyrosine, tryptophan, isonicotinylhydrazide, epigallocatechin gallate, and curcumin as reducing and stabilizing agents. The nanoparticles thus prepared showed surface corona and exhibited free radical scavenging and enzyme activities with limited cytotoxicity and genotoxicity. We have thus developed avenues for engineering the surface of nanoparticles for biological applications.
|
| 巻・号 |
10(1)
|
| ページ |
19713
|
| 公開日 |
2020-11-12
|
| DOI |
10.1038/s41598-020-75465-z
|
| PII |
10.1038/s41598-020-75465-z
|
| PMID |
33184324
|
| PMC |
PMC7665184
|
| MeSH |
Animals
Cell Survival
Cells, Cultured
DNA Damage*
Fibroblasts / cytology*
Fibroblasts / drug effects
Free Radical Scavengers / pharmacology*
Gold / chemistry*
Macrophages / cytology*
Macrophages / drug effects
Metal Nanoparticles / administration & dosage*
Metal Nanoparticles / chemistry
Mice
Peroxidase / metabolism
Silver / chemistry*
Surface Properties
|
| IF |
3.998
|
| リソース情報 |
| ヒト・動物細胞 |
RAW 264(RCB0535) |
