Reference - Detail
| RRC ID | 63180 |
|---|---|
| Author | Daifu T, Mikami M, Hiramatsu H, Iwai A, Umeda K, Noura M, Kubota H, Masuda T, Furuichi K, Takasaki S, Noguchi Y, Morita K, Bando T, Hirata M, Kataoka TR, Nakahata T, Kuwahara Y, Iehara T, Hosoi H, Takita J, Sugiyama H, Adachi S, Kamikubo Y. |
| Title | Suppression of malignant rhabdoid tumors through Chb-M'-mediated RUNX1 inhibition. |
| Journal | Pediatr Blood Cancer |
| Abstract |
Malignant rhabdoid tumor (MRT) is a rare and highly aggressive pediatric malignancy primarily affecting infants and young children. Intensive multimodal therapies currently given to MRT patients are not sufficiently potent to control this highly malignant tumor. Therefore, additive or alternative therapy for these patients with a poor prognosis is necessary. We herein demonstrated that the inhibition of runt-related transcription factor 1 (RUNX1) by novel alkylating conjugated pyrrole-imidazole (PI) polyamides, which specifically recognize and bind to RUNX-binding DNA sequences, was highly effective in the treatment of rhabdoid tumor cell lines in vitro as well as in an in vivo mouse model. Therefore, suppression of RUNX1 activity may be a novel strategy for MRT therapy. |
| Volume | 68(2) |
| Pages | e28789 |
| Published | 2021-2-1 |
| DOI | 10.1002/pbc.28789 |
| PMID | 33180377 |
| MeSH | Animals Antineoplastic Agents, Alkylating / therapeutic use* Cell Line, Tumor Chlorambucil / analogs & derivatives Chlorambucil / therapeutic use* Core Binding Factor Alpha 2 Subunit / antagonists & inhibitors* Core Binding Factor Alpha 2 Subunit / genetics Disease Models, Animal HEK293 Cells Humans Mice Mice, Inbred NOD Mice, SCID RNA Interference RNA, Small Interfering / genetics Rhabdoid Tumor / drug therapy* SMARCB1 Protein / genetics Xenograft Model Antitumor Assays |
| IF | 2.355 |
| Resource | |
| Human and Animal Cells | 293T(RCB2202) |