論文 - 詳細
| RRC ID | 63385 |
|---|---|
| 著者 | Liu X, Kwong A, Sihoe A, Chu KM. |
| タイトル | Plasma miR-940 may serve as a novel biomarker for gastric cancer. |
| ジャーナル | Tumour Biol |
| Abstract |
It was reported that circulating microRNAs could be applied as non-invasive biomarkers for cancer monitoring. The purpose of this study was to identify plasma miRNA that may serve as a novel biomarker for gastric cancer and to evaluate its clinical application. MicroRNA profiles were generated from plasma samples of 5 patients with gastric cancer (GC) versus 5 healthy controls (HC). MicroRNA-940 (miR-940) was one of the most downregulated miRNAs with fold change of 0.164. It was revealed that the expression of miR-940 was downregulated in both the initial set (N = 30, P < 0.0001) and the validation set (N = 80, P < 0.0001) of plasma samples of patients with gastric cancer. The sensitivity was obviously higher than the current biomarkers CEA and CA19-9 (81.25 % vs. 22.54 % and 15.71 %). MiR-940 was also significantly downregulated in gastric cancer tissue samples (N = 34, P = 0.0015), as well as in cancer cell lines (N = 7). Importantly, miR-940 was significantly highly expressed in stomach tissue samples than in other types of tissue samples including the liver, breast, thyroid, and lung. Moreover, there was a trend of lower expression of miR-940 from early to advanced stage of gastric cancer. Target prediction suggested that miR-940 regulated cell signaling including NF-κB and Wnt/β-catenin, as well as pathways of cell communication and adhesion. These pathways play critical roles in gastric cancer initiation and progression. It is the first report that miR-940 may mainly express in the stomach. Downregulation of plasma miR-940 may serve as a novel biomarker for detection of gastric cancer. |
| 巻・号 | 37(3) |
| ページ | 3589-97 |
| 公開日 | 2016-3-1 |
| DOI | 10.1007/s13277-015-4019-5 |
| PII | 10.1007/s13277-015-4019-5 |
| PMID | 26456959 |
| MeSH | Adult Aged Aged, 80 and over Biomarkers, Tumor / blood Biomarkers, Tumor / genetics* Cell Line, Tumor Down-Regulation Female Gene Expression Profiling / methods* Gene Expression Regulation, Neoplastic* Humans Male MicroRNAs / blood MicroRNAs / genetics* Middle Aged Oligonucleotide Array Sequence Analysis Reverse Transcriptase Polymerase Chain Reaction Stomach Neoplasms / blood Stomach Neoplasms / genetics* Stomach Neoplasms / pathology |
| IF | 3.65 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MKN7(RCB0999) MKN28(RCB1000) MKN45(RCB1001) |