論文 - 詳細
| RRC ID | 6343 |
|---|---|
| 著者 | Chesney MA, Lam N, Morgan DE, Phillips BT, Kimble J. |
| タイトル | C. elegans HLH-2/E/Daughterless controls key regulatory cells during gonadogenesis. |
| ジャーナル | Dev Biol |
| Abstract |
The Caenorhabditis elegans distal tip cell (DTC) provides a niche for germline stem cells in both hermaphrodites and males. The hermaphrodite distal tip cell (hDTC) also provides "leader" function to control gonadal elongation and shape, while in males, leader function is allocated to the linker cell (LC). Therefore, the male distal tip cell (mDTC) serves as a niche but not as a leader. The C. elegans homolog of E/Daughterless, HLH-2, was previously implicated in hDTC specification. Here we report that HLH-2 is also critical for hDTC maintenance, hDTC niche function and hDTC expression of a lag-2/DSL ligand reporter. We also find that HLH-2 functions in males to direct linker cell specification and to promote both mDTC maintenance and the mDTC niche function. We conclude that HLH-2 functions in both sexes to promote leader cell specification and DTC niche function. |
| 巻・号 | 331(1) |
| ページ | 14-25 |
| 公開日 | 2009-7-1 |
| DOI | 10.1016/j.ydbio.2009.04.015 |
| PII | S0012-1606(09)00258-9 |
| PMID | 19376107 |
| PMC | PMC2776051 |
| MeSH | Animals Basic Helix-Loop-Helix Transcription Factors / genetics* Caenorhabditis elegans / cytology Caenorhabditis elegans / genetics* Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / genetics* Disorders of Sex Development / genetics Female Genes, Regulator Genes, Reporter Genetic Markers Gonads / growth & development* Gonads / metabolism Green Fluorescent Proteins / genetics Male Mutation RNA Interference RNA, Helminth / genetics Recombination, Genetic |
| IF | 2.896 |
| 引用数 | 15 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| リソース情報 | |
| 線虫 | tm1768 |