| RRC ID |
63467
|
| 著者 |
Takakura M, Nakagawa R, Ota T, Kimura Y, Ng MY, Alia AG, Okuno H, Hirano Y.
|
| タイトル |
Rpd3/CoRest-mediated activity-dependent transcription regulates the flexibility in memory updating in Drosophila.
|
| ジャーナル |
Nat Commun
|
| Abstract |
Consolidated memory can be preserved or updated depending on the environmental change. Although such conflicting regulation may happen during memory updating, the flexibility of memory updating may have already been determined in the initial memory consolidation process. Here, we explored the gating mechanism for activity-dependent transcription in memory consolidation, which is unexpectedly linked to the later memory updating in Drosophila. Through proteomic analysis, we discovered that the compositional change in the transcriptional repressor, which contains the histone deacetylase Rpd3 and CoRest, acts as the gating mechanism that opens and closes the time window for activity-dependent transcription. Opening the gate through the compositional change in Rpd3/CoRest is required for memory consolidation, but closing the gate through Rpd3/CoRest is significant to limit future memory updating. Our data indicate that the flexibility of memory updating is determined through the initial activity-dependent transcription, providing a mechanism involved in defining memory state.
|
| 巻・号 |
12(1)
|
| ページ |
628
|
| 公開日 |
2021-1-27
|
| DOI |
10.1038/s41467-021-20898-x
|
| PII |
10.1038/s41467-021-20898-x
|
| PMID |
33504795
|
| PMC |
PMC7840730
|
| MeSH |
Acetylation
Animals
Behavior, Animal
Brain / physiology
Co-Repressor Proteins / metabolism*
Drosophila Proteins / metabolism*
Drosophila melanogaster / genetics*
Genetic Loci
Histone Deacetylase 1 / metabolism*
Memory / physiology*
Mushroom Bodies / innervation
Protein Binding
Protein Interaction Mapping
Protein Processing, Post-Translational
RNA, Messenger / genetics
RNA, Messenger / metabolism
Transcription, Genetic*
|
| IF |
12.121
|
| リソース情報 |
| ショウジョウバエ |
3878R-3
DGRC#130390 |
