論文 - 詳細
| RRC ID | 63614 |
|---|---|
| 著者 | Kaneda-Nakashima K, Zhang Z, Manabe Y, Shimoyama A, Kabayama K, Watabe T, Kanai Y, Ooe K, Toyoshima A, Shirakami Y, Yoshimura T, Fukuda M, Hatazawa J, Nakano T, Fukase K, Shinohara A. |
| タイトル | α-Emitting cancer therapy using 211 At-AAMT targeting LAT1. |
| ジャーナル | Cancer Sci |
| Abstract |
α-Methyl-l-tyrosine (AMT) has a high affinity for the cancer-specific l-type amino acid transporter 1 (LAT1). Therefore, we established an anti-cancer therapy, with 211 At-labeled α-methyl-l-tyrosine (211 At-AAMT) as a carrier of 211 At into tumors. 211 At-AAMT had high affinity for LAT1, inhibited tumor cell growth, and induced DNA double-stranded breaks in vitro. We evaluated the accumulation of 211 At-AAMT in vivo and the role of LAT1. Treatment with 0.4 MBq/mouse 211 At-AAMT inhibited tumor growth in the PANC-1 tumor model and 1 MBq/mouse 211 At-AAMT inhibited metastasis in the lung of the B16F10 metastasis model. Our results suggested that 211 At would be useful for anti-cancer therapy and that LAT1 is suitable as a target for radionuclide therapy. |
| 巻・号 | 112(3) |
| ページ | 1132-1140 |
| 公開日 | 2021-3-1 |
| DOI | 10.1111/cas.14761 |
| PMID | 33277750 |
| PMC | PMC7935802 |
| MeSH | Alpha Particles / therapeutic use* Animals Astatine / administration & dosage* Cell Line, Tumor DNA Breaks, Double-Stranded / radiation effects Disease Models, Animal Drug Carriers / pharmacology* Feasibility Studies Female HEK293 Cells Humans Large Neutral Amino Acid-Transporter 1 / metabolism* Male Mice Neoplasms / pathology Neoplasms / radiotherapy* Xenograft Model Antitumor Assays alpha-Methyltyrosine / pharmacology* |
| IF | 4.966 |
| リソース情報 | |
| ヒト・動物細胞 | B16F10(RCB2630) |