論文 - 詳細
| RRC ID | 63837 |
|---|---|
| 著者 | Hanif N, Murni A, Tanaka J. |
| タイトル | Sangiangols A and B, Two New Dolabellanes from an Indonesian Marine Soft Coral, Anthelia sp. |
| ジャーナル | Molecules |
| Abstract |
A new, rare trinor-dolabellane diterpenoid, sangiangol A (1), and one new dolabellane diterpenoid, sangiangol B (2), together with known cembranes and dolabellanes (3-8), were isolated from the ethyl acetate layer of an extract of an Indonesian marine soft coral, Anthelia sp. Compounds 1-8 exhibited moderate cytotoxicity against an NBT-T2 cell line (0.5-10 µg/mL). The structures of the new compounds were determined by analyzing their spectra and a molecular modelling study. A possible biosynthetic pathway for sangiangols A (1) and B (2) is presented. Cytotoxicity requires two epoxide rings or a chlorine atom, as in 4 (stolonidiol) and 5 (clavinflol B). |
| 巻・号 | 25(17) |
| 公開日 | 2020-8-21 |
| DOI | 10.3390/molecules25173803 |
| PII | molecules25173803 |
| PMID | 32825594 |
| PMC | PMC7504155 |
| MeSH | Animals Anthozoa / chemistry* Cell Survival / drug effects Cells, Cultured Cytotoxins / chemistry Cytotoxins / isolation & purification Cytotoxins / pharmacology* Diterpenes / chemistry* Diterpenes / isolation & purification Diterpenes / pharmacology* Epithelial Cells / drug effects Epithelial Cells / pathology* Indonesia Models, Molecular Rats Urinary Bladder / cytology Urinary Bladder / drug effects* |
| IF | 3.267 |
| リソース情報 | |
| ヒト・動物細胞 | NBT-T2(RCB1370) |