Reference - Detail
| RRC ID | 64101 |
|---|---|
| Author | Aida R, Hagiwara K, Okano K, Nakata K, Obata Y, Yamashita T, Yoshida K, Hagiwara H. |
| Title | miR-34a-5p might have an important role for inducing apoptosis by down-regulation of SNAI1 in apigenin-treated lung cancer cells. |
| Journal | Mol Biol Rep |
| Abstract |
Apigenin is a flavonoid with antioxidant and anticancer effects. It has been reported that apigenin inhibits proliferation, migration, and invasion and induces apoptosis in cultured lung cancer cells. However, there is little information on the involvement of microRNAs (miRNAs) in its effects. miRNA microarray analysis and polymerase-chain-reaction analysis of miRNAs revealed that treatment of human lung cancer A549 cells with apigenin up-regulated the level of miR-34a-5p. Furthermore, mRNA microarray analysis and the results of three microRNA target prediction tools showed that Snail Family Transcriptional Repressor 1 (SNAI1), which inhibits the induction of apoptosis, had its mRNA expression down-regulated in A549 cells treated with apigenin. Our findings suggest that apigenin might induce apoptosis by down-regulation of SNAI1 through up-regulation of miR-34a-5p in A549 cells. |
| Volume | 48(3) |
| Pages | 2291-2297 |
| Published | 2021-3-1 |
| DOI | 10.1007/s11033-021-06255-7 |
| PII | 10.1007/s11033-021-06255-7 |
| PMID | 33675467 |
| PMC | PMC8060201 |
| MeSH | A549 Cells Apigenin / pharmacology* Apoptosis / drug effects Apoptosis / genetics* Cell Survival / drug effects Cell Survival / genetics Down-Regulation / drug effects Down-Regulation / genetics* Gene Expression Regulation, Neoplastic / drug effects Humans Lung Neoplasms / genetics* Lung Neoplasms / pathology* MicroRNAs / genetics MicroRNAs / metabolism* Models, Biological RNA, Messenger / genetics RNA, Messenger / metabolism Snail Family Transcription Factors / genetics* Snail Family Transcription Factors / metabolism Up-Regulation / drug effects Up-Regulation / genetics |
| IF | 1.402 |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | A549(RCB0098) |