論文 - 詳細
| RRC ID | 64351 |
|---|---|
| 著者 | Ozawa S, Hori Y, Shimizu Y, Taniguchi A, Suzuki T, Wang W, Chiu YW, Koike R, Yokoshima S, Fukuyama T, Takatori S, Sohma Y, Kanai M, Tomita T. |
| タイトル | Photo-oxygenation by a biocompatible catalyst reduces amyloid-β levels in Alzheimer's disease mice. |
| ジャーナル | Brain |
| Abstract |
Amyloid formation and the deposition of the amyloid-β peptide are hallmarks of Alzheimer's disease pathogenesis. Immunotherapies using anti-amyloid-β antibodies have been highlighted as a promising approach for the prevention and treatment of Alzheimer's disease by enhancing microglial clearance of amyloid-β peptide. However, the efficiency of antibody delivery into the brain is limited, and therefore an alternative strategy to facilitate the clearance of brain amyloid is needed. We previously developed an artificial photo-oxygenation system using a low molecular weight catalytic compound. The photocatalyst specifically attached oxygen atoms to amyloids upon irradiation with light, and successfully reduced the neurotoxicity of aggregated amyloid-β via inhibition of amyloid formation. However, the therapeutic effect and mode of actions of the photo-oxygenation system in vivo remained unclear. In this study, we demonstrate that photo-oxygenation facilitates the clearance of aggregated amyloid-β from the brains of living Alzheimer's disease model mice, and enhances the microglial degradation of amyloid-β peptide. These results suggest that photo-oxygenation may represent a novel anti-amyloid-β strategy in Alzheimer's disease, which is compatible with immunotherapy. |
| 巻・号 | 144(6) |
| ページ | 1884-1897 |
| 公開日 | 2021-7-28 |
| DOI | 10.1093/brain/awab058 |
| PII | 6224831 |
| PMID | 33851209 |
| MeSH | Alzheimer Disease / pathology* Amyloid beta-Peptides / drug effects* Amyloid beta-Peptides / metabolism* Animals Boron Compounds / pharmacology* Brain / drug effects* Brain / pathology Disease Models, Animal Humans Mice Microglia / metabolism Phototherapy / methods Protein Aggregates / drug effects |
| IF | 11.337 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 21 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MG6(RCB2403) |