論文 - 詳細
| RRC ID | 64770 |
|---|---|
| 著者 | Liu Z, Kimura Y, Higashijima SI, Hildebrand DGC, Morgan JL, Bagnall MW. |
| タイトル | Central Vestibular Tuning Arises from Patterned Convergence of Otolith Afferents. |
| ジャーナル | Neuron |
| Abstract |
As sensory information moves through the brain, higher-order areas exhibit more complex tuning than lower areas. Though models predict that complexity arises via convergent inputs from neurons with diverse response properties, in most vertebrate systems, convergence has only been inferred rather than tested directly. Here, we measure sensory computations in zebrafish vestibular neurons across multiple axes in vivo. We establish that whole-cell physiological recordings reveal tuning of individual vestibular afferent inputs and their postsynaptic targets. Strong, sparse synaptic inputs can be distinguished by their amplitudes, permitting analysis of afferent convergence in vivo. An independent approach, serial-section electron microscopy, supports the inferred connectivity. We find that afferents with similar or differing preferred directions converge on central vestibular neurons, conferring more simple or complex tuning, respectively. Together, these results provide a direct, quantifiable demonstration of feedforward input convergence in vivo. |
| 巻・号 | 108(4) |
| ページ | 748-762.e4 |
| 公開日 | 2020-11-25 |
| DOI | 10.1016/j.neuron.2020.08.019 |
| PII | S0896-6273(20)30650-4 |
| PMID | 32937099 |
| PMC | PMC7704800 |
| MeSH | Animals Electric Stimulation Evoked Potentials, Somatosensory / physiology Gene Knock-In Techniques Microscopy, Electron Neurons / physiology Neurons / ultrastructure Neurons, Afferent / physiology* Neurons, Afferent / ultrastructure Otolithic Membrane / physiology* Vestibular Nuclei / physiology* Vestibular Nuclei / ultrastructure Zebrafish |
| IF | 14.415 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 14 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(nefma:Gal4) |