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  • Search Condition : Filter (MeSH = Gene Knock-In Techniques)
Species Resource Title
Rats Seac:Lister Hooded (StrainID=1272) A novel technique for large-fragment knock-in animal production without ex vivo handling of zygotes.
DNA material pROSA26CAG-GFP-tdsRed (RDB19441) Novel ROSA26 Cre-reporter knock-in C57BL/6N mice exhibiting green emission before and red emission after Cre-mediated recombination.
Human and Animal Cells NIH3T3-3-4(RCB1862) In vivo role of phosphorylation of cryptochrome 2 in the mouse circadian clock.
DNA material pCALNL5 (RDB01862) Endothelial expression of human amyloid precursor protein leads to amyloid β in the blood and induces cerebral amyloid angiopathy in knock-in mice.
Zebrafish Tol-056 Loss of PIGK function causes severe infantile encephalopathy and extensive neuronal apoptosis.
Medaka TG1421 Tg(cdh2-eGFP) , TG1422 Tg(eGFP-cbx1b) , TG1423 Tg(eGFP-rab11a) , TG1424 Tg(mapre1b-Linker-3xFlag-mScarlet) , TG1425 Tg(mNeonGreen-HAtag-Linker-myosinh) , TG1426 Tg(mScarlet-pcna) Endogenous protein tagging in medaka using a simplified CRISPR/Cas9 knock-in approach.
Zebrafish Tg(nefma:Gal4) Central Vestibular Tuning Arises from Patterned Convergence of Otolith Afferents.
Human and Animal Cells ST2(RCB0224) BMP3 suppresses osteoblast differentiation of bone marrow stromal cells via interaction with Acvr2b.
DNA material T7-NLS hCas9-pA (RDB13130) , pT7-hCas9-mC-polyA (RDB14423) , T7-3xFLAG-NLS-hCAS9-NLS-pA (RDB14602) , T7-3xFLAG-NLS-hCAS9-Cdt1-NLS-pA (RDB14604) , px330-mC (RDB14406) , pX330-Tyr-L (RDB14410) , pX330-Tyr-R (RDB14411) , pX330-mC-Tyr-L (RDB14412) , pX330-mC-Tyr-R (RDB14413) , pX330-Dmd-L (RDB16004) , ... Efficient production of large deletion and gene fragment knock-in mice mediated by genome editing with Cas9-mouse Cdt1 in mouse zygotes.
DNA material Genome Network Project Human cDNA IRAK049F12 (HGX019732) TBX5 R264K acts as a modifier to develop dilated cardiomyopathy in mice independently of T-box pathway.
Human and Animal Cells 454E2(HPS0077) Spatiotemporal imaging documented the maturation of the cardiomyocytes from human induced pluripotent stem cells.
Human and Animal Cells HUDEP-2(RCB4557) Acute depletion of CTCF directly affects MYC regulation through loss of enhancer-promoter looping.
C.elegans tm776 Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration.
Drosophila 5183R-1 , 5183R-2 , 4322R-1 , 4780R-3 , 4780R-1 , 9668R-2 , 31640R-3 , 7000R-2 , 9668R-1 , 7227R-1 , ... An in vivo RNAi screen uncovers the role of AdoR signaling and adenosine deaminase in controlling intestinal stem cell activity.
Human and Animal Cells 293T(RCB2202) Sequence-specific retrotransposition of 28S rDNA-specific LINE R2Ol in human cells.
Algae NIES-48 Highly efficient transgene-free targeted mutagenesis and single-stranded oligodeoxynucleotide-mediated precise knock-in in the industrial microalga Euglena gracilis using Cas9 ribonucleoproteins.
Human and Animal Cells Ba/F3(RCB0805) Development of a new knock-in mouse model and evaluation of pharmacological activities of lusutrombopag, a novel, nonpeptidyl small-molecule agonist of the human thrombopoietin receptor c-Mpl.
Human and Animal Cells GS-DG1(AES0002) , Mvh-Venus GS(AES0196) Generating Genetically Engineered Mice Using a Spermatogonial Stem Cell-Mediated Method.
C.elegans tm3464 Genetic Suppression of Basement Membrane Defects in Caenorhabditis elegans by Gain of Function in Extracellular Matrix and Cell-Matrix Attachment Genes.
Human and Animal Cells CHO-K1(RCB0285) Biased genome editing using the local accumulation of DSB repair molecules system.