Reference - Detail
RRC ID | 64813 |
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Author | Saito Y, Nakamura S, Chinen N, Shimazawa M, Hara H. |
Title | Effects of anti-osteoporosis drugs against dexamethasone-induced osteoporosis-like phenotype using a zebrafish scale-regeneration model. |
Journal | J Pharmacol Sci |
Abstract |
There are several animal models of glucocorticoid-induced osteoporosis (GIOP), but each requires a long time to evaluate drug effects. Zebrafish scales are classified as dermal bone and potentially represent a convenient animal model of GIOP because they rapidly regenerate following their removal. We clarified that dexamethasone-treated regenerating scales showed malformations, decreased size and circularity. Anti-osteoporosis drugs rescued the scale malformation phenotype eight-days following the removal of scales. Hence, the dexamethasone-induced regenerating scale malformation model may be a useful animal model for discovering drugs to treat GIOP. |
Volume | 143(2) |
Pages | 117-121 |
Published | 2020-6-1 |
DOI | 10.1016/j.jphs.2020.02.011 |
PII | S1347-8613(20)30027-X |
PMID | 32220570 |
MeSH | Animal Scales / pathology* Animal Scales / physiology* Animals Bone Density Conservation Agents / pharmacology Bone Density Conservation Agents / therapeutic use* Dexamethasone / adverse effects* Disease Models, Animal* Osteoporosis / chemically induced* Osteoporosis / drug therapy* Phenotype Regeneration* / drug effects Zebrafish |
IF | 2.835 |
Resource | |
Zebrafish | RIKEN WT |