論文 - 詳細
| RRC ID | 65186 |
|---|---|
| 著者 | Flynn SM, Chen C, Artan M, Barratt S, Crisp A, Nelson GM, Peak-Chew SY, Begum F, Skehel M, de Bono M. |
| タイトル | MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity. |
| ジャーナル | Nat Commun |
| Abstract |
Besides pro-inflammatory roles, the ancient cytokine interleukin-17 (IL-17) modulates neural circuit function. We investigate IL-17 signaling in neurons, and the extent it can alter organismal phenotypes. We combine immunoprecipitation and mass spectrometry to biochemically characterize endogenous signaling complexes that function downstream of IL-17 receptors in C. elegans neurons. We identify the paracaspase MALT-1 as a critical output of the pathway. MALT1 mediates signaling from many immune receptors in mammals, but was not previously implicated in IL-17 signaling or nervous system function. C. elegans MALT-1 forms a complex with homologs of Act1 and IRAK and appears to function both as a scaffold and a protease. MALT-1 is expressed broadly in the C. elegans nervous system, and neuronal IL-17-MALT-1 signaling regulates multiple phenotypes, including escape behavior, associative learning, immunity and longevity. Our data suggest MALT1 has an ancient role modulating neural circuit function downstream of IL-17 to remodel physiology and behavior. |
| 巻・号 | 11(1) |
| ページ | 2099 |
| 公開日 | 2020-4-29 |
| DOI | 10.1038/s41467-020-15872-y |
| PII | 10.1038/s41467-020-15872-y |
| PMID | 32350248 |
| PMC | PMC7190641 |
| MeSH | Animals Behavior, Animal Caenorhabditis elegans / drug effects Caenorhabditis elegans / genetics Caenorhabditis elegans / immunology* Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism* Gene Expression Regulation / drug effects Green Fluorescent Proteins / metabolism Immunity* / drug effects Interleukin-17 / metabolism* Interneurons / drug effects Interneurons / physiology Longevity* / drug effects Models, Biological Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein / metabolism* Neurons / drug effects Neurons / metabolism* Oxygen / pharmacology Signal Transduction / drug effects Subcellular Fractions / metabolism Transgenes |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2167 tm5866 tm3036 tm5218 |