| RRC ID |
65187
|
| 著者 |
Watteyne J, Peymen K, Van der Auwera P, Borghgraef C, Vandewyer E, Van Damme S, Rutten I, Lammertyn J, Jelier R, Schoofs L, Beets I.
|
| タイトル |
Neuromedin U signaling regulates retrieval of learned salt avoidance in a C. elegans gustatory circuit.
|
| ジャーナル |
Nat Commun
|
| Abstract |
Learning and memory are regulated by neuromodulatory pathways, but the contribution and temporal requirement of most neuromodulators in a learning circuit are unknown. Here we identify the evolutionarily conserved neuromedin U (NMU) neuropeptide family as a regulator of C. elegans gustatory aversive learning. The NMU homolog CAPA-1 and its receptor NMUR-1 are required for the retrieval of learned salt avoidance. Gustatory aversive learning requires the release of CAPA-1 neuropeptides from sensory ASG neurons that respond to salt stimuli in an experience-dependent manner. Optogenetic silencing of CAPA-1 neurons blocks the expression, but not the acquisition, of learned salt avoidance. CAPA-1 signals through NMUR-1 in AFD sensory neurons to modulate two navigational strategies for salt chemotaxis. Aversive conditioning thus recruits NMU signaling to modulate locomotor programs for expressing learned avoidance behavior. Because NMU signaling is conserved across bilaterian animals, our findings incite further research into its function in other learning circuits.
|
| 巻・号 |
11(1)
|
| ページ |
2076
|
| 公開日 |
2020-4-29
|
| DOI |
10.1038/s41467-020-15964-9
|
| PII |
10.1038/s41467-020-15964-9
|
| PMID |
32350283
|
| PMC |
PMC7190830
|
| MeSH |
Amino Acid Sequence
Animals
Animals, Genetically Modified
Avoidance Learning / physiology*
Behavior, Animal
Caenorhabditis elegans / physiology*
Caenorhabditis elegans Proteins / chemistry
Caenorhabditis elegans Proteins / metabolism*
Calcium / metabolism
Food
Models, Biological
Mutation / genetics
Nerve Net / physiology*
Neuropeptides / metabolism*
Phylogeny
Sensory Receptor Cells / physiology
Signal Transduction*
Sodium Chloride / adverse effects*
Taste / physiology*
|
| リソース情報 |
| 線虫 |
tm3764 |
