論文 - 詳細
| RRC ID | 65205 |
|---|---|
| 著者 | Castellano-Pozo M, Pacheco S, Sioutas G, Jaso-Tamame AL, Dore MH, Karimi MM, Martinez-Perez E. |
| タイトル | Surveillance of cohesin-supported chromosome structure controls meiotic progression. |
| ジャーナル | Nat Commun |
| Abstract |
Chromosome movements and programmed DNA double-strand breaks (DSBs) promote homologue pairing and initiate recombination at meiosis onset. Meiotic progression involves checkpoint-controlled termination of these events when all homologue pairs achieve synapsis and form crossover precursors. Exploiting the temporo-spatial organisation of the C. elegans germline and time-resolved methods of protein removal, we show that surveillance of the synaptonemal complex (SC) controls meiotic progression. In nuclei with fully synapsed homologues and crossover precursors, removing different meiosis-specific cohesin complexes, which are individually required for SC stability, or a SC central region component causes functional redeployment of the chromosome movement and DSB machinery, triggering whole-nucleus reorganisation. This apparent reversal of the meiotic programme requires CHK-2 kinase reactivation via signalling from chromosome axes containing HORMA proteins, but occurs in the absence of transcriptional changes. Our results uncover an unexpected plasticity of the meiotic programme and show how chromosome signalling orchestrates nuclear organisation and meiotic progression. |
| 巻・号 | 11(1) |
| ページ | 4345 |
| 公開日 | 2020-8-28 |
| DOI | 10.1038/s41467-020-18219-9 |
| PII | 10.1038/s41467-020-18219-9 |
| PMID | 32859945 |
| PMC | PMC7455720 |
| MeSH | Animals Caenorhabditis elegans / genetics* Caenorhabditis elegans Proteins / metabolism Cell Cycle Checkpoints Cell Cycle Proteins / metabolism* Checkpoint Kinase 2 / metabolism Chromosomal Proteins, Non-Histone / metabolism* Chromosome Pairing Chromosome Structures / metabolism* Cohesins DNA Breaks, Double-Stranded Meiosis / physiology* Synaptonemal Complex / metabolism |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1857 |