論文 - 詳細
| RRC ID | 65209 |
|---|---|
| 著者 | Mao K, Breen P, Ruvkun G. |
| タイトル | Mitochondrial dysfunction induces RNA interference in C. elegans through a pathway homologous to the mammalian RIG-I antiviral response. |
| ジャーナル | PLoS Biol |
| Abstract |
RNA interference (RNAi) is an antiviral pathway common to many eukaryotes that detects and cleaves foreign nucleic acids. In mammals, mitochondrially localized proteins such as mitochondrial antiviral signaling (MAVS), retinoic acid-inducible gene I (RIG-I), and melanoma differentiation-associated protein 5 (MDA5) mediate antiviral responses. Here, we report that mitochondrial dysfunction in Caenorhabditis elegans activates RNAi-directed silencing via induction of a pathway homologous to the mammalian RIG-I helicase viral response pathway. The induction of RNAi also requires the conserved RNA decapping enzyme EOL-1/DXO. The transcriptional induction of eol-1 requires DRH-1 as well as the mitochondrial unfolded protein response (UPRmt). Upon mitochondrial dysfunction, EOL-1 is concentrated into foci that depend on the transcription of mitochondrial RNAs that may form double-stranded RNA (dsRNA), as has been observed in mammalian antiviral responses. Enhanced RNAi triggered by mitochondrial dysfunction is necessary for the increase in longevity that is induced by mitochondrial dysfunction. |
| 巻・号 | 18(12) |
| ページ | e3000996 |
| 公開日 | 2020-12-1 |
| DOI | 10.1371/journal.pbio.3000996 |
| PII | PBIOLOGY-D-20-01834 |
| PMID | 33264285 |
| PMC | PMC7735679 |
| MeSH | Adaptor Proteins, Signal Transducing Animals Caenorhabditis elegans / genetics Caenorhabditis elegans Proteins / metabolism DEAD Box Protein 58 / metabolism* DEAD Box Protein 58 / physiology DEAD-box RNA Helicases / metabolism Gene Expression Regulation / genetics Interferon-Induced Helicase, IFIH1 / metabolism Mitochondria / metabolism* Mitochondria / physiology RNA Interference / physiology* RNA, Double-Stranded / genetics RNA, Small Interfering / genetics RNA, Viral / genetics Signal Transduction / genetics |
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オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 22 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1329 |