論文 - 詳細
| RRC ID | 65231 |
|---|---|
| 著者 | Zhu D, Wu X, Zhou J, Li X, Huang X, Li J, Wu J, Bian Q, Wang Y, Tian Y. |
| タイトル | NuRD mediates mitochondrial stress-induced longevity via chromatin remodeling in response to acetyl-CoA level. |
| ジャーナル | Sci Adv |
| Abstract |
Mild mitochondrial stress experienced early in life can have beneficial effects on the life span of organisms through epigenetic regulations. Here, we report that acetyl-coenzyme A (CoA) represents a critical mitochondrial signal to regulate aging through the chromatin remodeling and histone deacetylase complex (NuRD) in Caenorhabditis elegans. Upon mitochondrial stress, the impaired tricarboxylic acid cycle results in a decreased level of citrate, which accounts for reduced production of acetyl-CoA and consequently induces nuclear accumulation of the NuRD and a homeodomain-containing transcription factor DVE-1, thereby enabling decreased histone acetylation and chromatin reorganization. The metabolic stress response is thus established during early life and propagated into adulthood to allow transcriptional regulation for life-span extension. Furthermore, adding nutrients to restore acetyl-CoA production is sufficient to counteract the chromatin changes and diminish the longevity upon mitochondrial stress. Our findings uncover the molecular mechanism of the metabolite-mediated epigenome for the regulation of organismal aging. |
| 巻・号 | 6(31) |
| ページ | eabb2529 |
| 公開日 | 2020-7-1 |
| DOI | 10.1126/sciadv.abb2529 |
| PII | abb2529 |
| PMID | 32789178 |
| PMC | PMC7400466 |
| MeSH | Acetyl Coenzyme A / metabolism Acetylation Animals Caenorhabditis elegans / metabolism Chromatin / metabolism Chromatin Assembly and Disassembly* Histones / metabolism Longevity* |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 29 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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