論文 - 詳細
| RRC ID | 65279 |
|---|---|
| 著者 | Charest J, Daniele T, Wang J, Bykov A, Mandlbauer A, Asparuhova M, Röhsner J, Gutiérrez-Pérez P, Cochella L. |
| タイトル | Combinatorial Action of Temporally Segregated Transcription Factors. |
| ジャーナル | Dev Cell |
| Abstract |
Combinatorial action of transcription factors (TFs) with partially overlapping expression is a widespread strategy to generate novel gene-expression patterns and, thus, cellular diversity. Known mechanisms underlying combinatorial activity require co-expression of TFs within the same cell. Here, we describe the mechanism by which two TFs that are never co-expressed generate a new, intersectional expression pattern in C. elegans embryos: lineage-specific priming of a gene by a transiently expressed TF generates a unique intersection with a second TF acting on the same gene four cell divisions later; the second TF is expressed in multiple cells but only activates transcription in those where priming occurred. Early induction of active transcription is necessary and sufficient to establish a competent state, maintained by broadly expressed regulators in the absence of the initial trigger. We uncover additional cells diversified through this mechanism. Our findings define a mechanism for combinatorial TF activity with important implications for generation of cell-type diversity. |
| 巻・号 | 55(4) |
| ページ | 483-499.e7 |
| 公開日 | 2020-11-23 |
| DOI | 10.1016/j.devcel.2020.09.002 |
| PII | S1534-5807(20)30672-9 |
| PMID | 33002421 |
| PMC | PMC7704111 |
| MeSH | Animals Caenorhabditis elegans / cytology Caenorhabditis elegans / embryology Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism Cell Lineage Embryo, Nonmammalian / metabolism Gene Expression Regulation Genetic Loci Neurons / metabolism Protein Binding Time Factors Transcription Factors / metabolism* Transcription, Genetic |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 82 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm314 tm581 |