論文 - 詳細
| RRC ID | 65333 |
|---|---|
| 著者 | Honer M, Buscemi K, Barrett N, Riazati N, Orlando G, Nelson MD. |
| タイトル | Orcokinin neuropeptides regulate sleep in Caenorhabditis elegans. |
| ジャーナル | J Neurogenet |
| Abstract |
Orcokinin neuropeptides are conserved among ecdysozoans, but their functions are incompletely understood. Here, we report a role for orcokinin neuropeptides in the regulation of sleep in the nematode Caenorhabditis elegans. The C. elegans orcokinin peptides, which are encoded by the nlp-14 and nlp-15 genes, are necessary and sufficient for quiescent behaviors during developmentally timed sleep (DTS) as well as during stress-induced sleep (SIS). The five orcokinin neuropeptides encoded by nlp-14 have distinct but overlapping functions in the regulation of movement and defecation quiescence during SIS. We suggest that orcokinins may regulate behavioral components of sleep-like states in nematodes and other ecdysozoans. |
| 巻・号 | 34(3-4) |
| ページ | 440-452 |
| 公開日 | 2020-1-1 |
| DOI | 10.1080/01677063.2020.1830084 |
| PMID | 33044108 |
| PMC | PMC7850316 |
| MeSH | Animals Animals, Genetically Modified Arthropods / physiology CRISPR-Cas Systems Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology* Conserved Sequence Defecation / physiology Gene Editing Genes, Helminth Hot Temperature Loss of Function Mutation Motor Activity Neurons / metabolism Neuropeptides / genetics Neuropeptides / physiology* Sequence Alignment Sleep / genetics Sleep / physiology* Species Specificity Stress, Physiological / physiology Transgenes Up-Regulation |
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オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1880 |