RRC ID 65333
Author Honer M, Buscemi K, Barrett N, Riazati N, Orlando G, Nelson MD.
Title Orcokinin neuropeptides regulate sleep in Caenorhabditis elegans.
Journal J Neurogenet
Abstract Orcokinin neuropeptides are conserved among ecdysozoans, but their functions are incompletely understood. Here, we report a role for orcokinin neuropeptides in the regulation of sleep in the nematode Caenorhabditis elegans. The C. elegans orcokinin peptides, which are encoded by the nlp-14 and nlp-15 genes, are necessary and sufficient for quiescent behaviors during developmentally timed sleep (DTS) as well as during stress-induced sleep (SIS). The five orcokinin neuropeptides encoded by nlp-14 have distinct but overlapping functions in the regulation of movement and defecation quiescence during SIS. We suggest that orcokinins may regulate behavioral components of sleep-like states in nematodes and other ecdysozoans.
Volume 34(3-4)
Pages 440-452
Published 2020-1-1
DOI 10.1080/01677063.2020.1830084
PMID 33044108
PMC PMC7850316
MeSH Animals Animals, Genetically Modified Arthropods / physiology CRISPR-Cas Systems Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology* Conserved Sequence Defecation / physiology Gene Editing Genes, Helminth Hot Temperature Loss of Function Mutation Motor Activity Neurons / metabolism Neuropeptides / genetics Neuropeptides / physiology* Sequence Alignment Sleep / genetics Sleep / physiology* Species Specificity Stress, Physiological / physiology Transgenes Up-Regulation
Resource
C.elegans tm1880