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  • Search Condition : Filter (MeSH = Loss of Function Mutation)
Species Resource Title
C.elegans tm6722 , tm6526 Effector and regulator: Diverse functions of C. elegans C-type lectin-like domain proteins.
Drosophila DGRC#111477 Drosophila septin interacting protein 1 regulates neurogenesis in the early developing larval brain.
Arabidopsis / Cultured plant cells, genes psi00016 Gibberellin Signaling Promotes the Secondary Growth of Storage Roots in Panax ginseng.
Medaka TG1403 olvas-DsRedExpress Generation of biallelic F0 mutants in medaka using the CRISPR/Cas9 system.
C.elegans tm1880 Orcokinin neuropeptides regulate sleep in Caenorhabditis elegans.
C.elegans tm1036 The Snail transcription factor CES-1 regulates glutamatergic behavior in C. elegans.
Drosophila 4349R-3 , 4963R-2 Elevating bioavailable iron levels in mitochondria suppresses the defective phenotypes caused by PINK1 loss-of-function in Drosophila melanogaster.
Drosophila CAS-0004 The Classic Lobe Eye Phenotype of Drosophila Is Caused by Transposon Insertion-Induced Misexpression of a Zinc-Finger Transcription Factor.
C.elegans tm3395 , tm4263 Akirin Is Required for Muscle Function and Acts Through the TGF-β Sma/Mab Signaling Pathway in Caenorhabditis elegans Development.
C.elegans tm776 Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration.
Human and Animal Cells HeLa(RCB0007) ZIP kinase phosphorylated and activated by Rho kinase/ROCK contributes to cytokinesis in mammalian cultured cells.
Drosophila 31783R-1 , 31783R-2 Jouvence a small nucleolar RNA required in the gut extends lifespan in Drosophila.
Drosophila The fruit fly at the interface of diagnosis and pathogenic mechanisms of rare and common human diseases.
Lotus / Glycine ミヤコグサDNA Loss-of-function of ASPARTIC PEPTIDASE NODULE-INDUCED 1 (APN1) in Lotus japonicus restricts efficient nitrogen-fixing symbiosis with specific Mesorhizobium loti strains.
C.elegans tm6691 , tm4374 , tm2862 , tm2572 UNG-1 and APN-1 are the major enzymes to efficiently repair 5-hydroxymethyluracil DNA lesions in C. elegans.
Human and Animal Cells PC-9(RCB4455) Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation.
Drosophila 5115R-2 Drosophila jumu modulates apoptosis via a JNK-dependent pathway and is required for other processes in wing development.
C.elegans tm3464 Genetic Suppression of Basement Membrane Defects in Caenorhabditis elegans by Gain of Function in Extracellular Matrix and Cell-Matrix Attachment Genes.
Drosophila DGRC#118829 , DGRC#118830 Genetic Analyses of Elys Mutations in Drosophila Show Maternal-Effect Lethality and Interactions with Nucleoporin Genes.
Human and Animal Cells HuH-28(RCB1943) PARP inhibitor olaparib sensitizes cholangiocarcinoma cells to radiation.