| RRC ID |
65333
|
| 著者 |
Honer M, Buscemi K, Barrett N, Riazati N, Orlando G, Nelson MD.
|
| タイトル |
Orcokinin neuropeptides regulate sleep in Caenorhabditis elegans.
|
| ジャーナル |
J Neurogenet
|
| Abstract |
Orcokinin neuropeptides are conserved among ecdysozoans, but their functions are incompletely understood. Here, we report a role for orcokinin neuropeptides in the regulation of sleep in the nematode Caenorhabditis elegans. The C. elegans orcokinin peptides, which are encoded by the nlp-14 and nlp-15 genes, are necessary and sufficient for quiescent behaviors during developmentally timed sleep (DTS) as well as during stress-induced sleep (SIS). The five orcokinin neuropeptides encoded by nlp-14 have distinct but overlapping functions in the regulation of movement and defecation quiescence during SIS. We suggest that orcokinins may regulate behavioral components of sleep-like states in nematodes and other ecdysozoans.
|
| 巻・号 |
34(3-4)
|
| ページ |
440-452
|
| 公開日 |
2020-1-1
|
| DOI |
10.1080/01677063.2020.1830084
|
| PMID |
33044108
|
| PMC |
PMC7850316
|
| MeSH |
Animals
Animals, Genetically Modified
Arthropods / physiology
CRISPR-Cas Systems
Caenorhabditis elegans / genetics
Caenorhabditis elegans / physiology*
Caenorhabditis elegans Proteins / genetics
Caenorhabditis elegans Proteins / physiology*
Conserved Sequence
Defecation / physiology
Gene Editing
Genes, Helminth
Hot Temperature
Loss of Function Mutation
Motor Activity
Neurons / metabolism
Neuropeptides / genetics
Neuropeptides / physiology*
Sequence Alignment
Sleep / genetics
Sleep / physiology*
Species Specificity
Stress, Physiological / physiology
Transgenes
Up-Regulation
|
| リソース情報 |
| 線虫 |
tm1880 |
