論文 - 詳細
| RRC ID | 65345 |
|---|---|
| 著者 | Carpenter BS, Lee TW, Plott CF, Rodriguez JD, Brockett JS, Myrick DA, Katz DJ. |
| タイトル | Caenorhabditis elegans establishes germline versus soma by balancing inherited histone methylation. |
| ジャーナル | Development |
| Abstract |
Formation of a zygote is coupled with extensive epigenetic reprogramming to enable appropriate inheritance of histone methylation and prevent developmental delays. In Caenorhabditis elegans, this reprogramming is mediated by the H3K4me2 demethylase SPR-5 and the H3K9 methyltransferase, MET-2. In contrast, the H3K36 methyltransferase MES-4 maintains H3K36me2/3 at germline genes between generations to facilitate re-establishment of the germline. To determine whether the MES-4 germline inheritance pathway antagonizes spr-5; met-2 reprogramming, we examined the interaction between these two pathways. We found that the developmental delay of spr-5; met-2 mutant progeny is associated with ectopic H3K36me3 and the ectopic expression of MES-4-targeted germline genes in somatic tissues. Furthermore, the developmental delay is dependent upon MES-4 and the H3K4 methyltransferase, SET-2. We propose that MES-4 prevents crucial germline genes from being repressed by antagonizing maternal spr-5; met-2 reprogramming. Thus, the balance of inherited histone modifications is necessary to distinguish germline versus soma and prevent developmental delay.This article has an associated 'The people behind the papers' interview. |
| 巻・号 | 148(3) |
| 公開日 | 2021-2-10 |
| DOI | 10.1242/dev.196600 |
| PII | dev.196600 |
| PMID | 33462111 |
| PMC | PMC7888751 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism Carisoprodol / metabolism* Epigenesis, Genetic Epigenomics Gene Expression Gene Knockdown Techniques Germ Cells / metabolism* Histones / metabolism* Methylation Protein Processing, Post-Translational |
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