論文 - 詳細
| RRC ID | 65347 |
|---|---|
| 著者 | Okabe E, Uno M, Kishimoto S, Nishida E. |
| タイトル | Intertissue small RNA communication mediates the acquisition and inheritance of hormesis in Caenorhabditis elegans. |
| ジャーナル | Commun Biol |
| Abstract |
Environmental conditions can cause phenotypic changes, part of which can be inherited by subsequent generations via soma-to-germline communication. However, the signaling molecules or pathways that mediate intertissue communication remain unclear. Here, we show that intertissue small RNA communication systems play a key role in the acquisition and inheritance of hormesis effects - stress-induced stress resistance - in Caenorhabditis elegans. The miRNA-processing enzyme DRSH-1 is involved in both the acquisition and the inheritance of hormesis, whereas worm-specific Argonaute (WAGO) proteins, which function with endo-siRNAs, are involved only in its inheritance. Further analyses demonstrate that the miRNA production system in the neuron and the small RNA transport machinery in the intestine are both essential for its acquisition and that both the transport of small RNAs in the germline and the germline Argonaute HRDE-1 complex are required for its inheritance. Our results thus demonstrate that overlapping and distinct roles of small RNA systems in the acquisition and inheritance of hormesis effects. |
| 巻・号 | 4(1) |
| ページ | 207 |
| 公開日 | 2021-2-16 |
| DOI | 10.1038/s42003-021-01692-3 |
| PII | 10.1038/s42003-021-01692-3 |
| PMID | 33594200 |
| PMC | PMC7886853 |
| MeSH | Animals Animals, Genetically Modified Argonaute Proteins / genetics Argonaute Proteins / metabolism* Caenorhabditis elegans / enzymology* Caenorhabditis elegans / genetics Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Heredity Histone Methyltransferases / genetics Histone Methyltransferases / metabolism Histone-Lysine N-Methyltransferase / genetics Histone-Lysine N-Methyltransferase / metabolism Hormesis / genetics* Intestines MicroRNAs / genetics MicroRNAs / metabolism* Neurons / metabolism Osmotic Pressure Oxidative Stress RNA Interference RNA Transport* RNA, Small Interfering / genetics RNA, Small Interfering / metabolism* Ribonuclease III / genetics Ribonuclease III / metabolism* |
| リソース情報 | |
| 線虫 | tm12491 tm1200 |