RRC ID 65716
Author Kotliński M, Knizewski L, Muszewska A, Rutowicz K, Lirski M, Schmidt A, Baroux C, Ginalski K, Jerzmanowski A.
Title Phylogeny-Based Systematization of Arabidopsis Proteins with Histone H1 Globular Domain.
Journal Plant Physiol
Abstract H1 (or linker) histones are basic nuclear proteins that possess an evolutionarily conserved nucleosome-binding globular domain, GH1. They perform critical functions in determining the accessibility of chromatin DNA to trans-acting factors. In most metazoan species studied so far, linker histones are highly heterogenous, with numerous nonallelic variants cooccurring in the same cells. The phylogenetic relationships among these variants as well as their structural and functional properties have been relatively well established. This contrasts markedly with the rather limited knowledge concerning the phylogeny and structural and functional roles of an unusually diverse group of GH1-containing proteins in plants. The dearth of information and the lack of a coherent phylogeny-based nomenclature of these proteins can lead to misunderstandings regarding their identity and possible relationships, thereby hampering plant chromatin research. Based on published data and our in silico and high-throughput analyses, we propose a systematization and coherent nomenclature of GH1-containing proteins of Arabidopsis (Arabidopsis thaliana [L.] Heynh) that will be useful for both the identification and structural and functional characterization of homologous proteins from other plant species.
Volume 174(1)
Pages 27-34
Published 2017-5-1
DOI 10.1104/pp.16.00214
PII pp.16.00214
PMID 28298478
PMC PMC5411143
MeSH Arabidopsis / genetics* Arabidopsis / metabolism Arabidopsis Proteins / classification Arabidopsis Proteins / genetics* Arabidopsis Proteins / metabolism Binding Sites / genetics Databases, Genetic Databases, Protein Histones / classification Histones / genetics* Histones / metabolism Phylogeny* Plant Proteins / classification Plant Proteins / genetics Plant Proteins / metabolism Plants / classification Plants / genetics Plants / metabolism Species Specificity
IF 6.305
Resource
Arabidopsis / Cultured plant cells, genes rpc00008