| RRC ID |
65888
|
| 著者 |
Lin Q, Manley J, Helmreich M, Schlumm F, Li JM, Robson DN, Engert F, Schier A, Nöbauer T, Vaziri A.
|
| タイトル |
Cerebellar Neurodynamics Predict Decision Timing and Outcome on the Single-Trial Level.
|
| ジャーナル |
Cell
|
| Abstract |
Goal-directed behavior requires the interaction of multiple brain regions. How these regions and their interactions with brain-wide activity drive action selection is less understood. We have investigated this question by combining whole-brain volumetric calcium imaging using light-field microscopy and an operant-conditioning task in larval zebrafish. We find global, recurring dynamics of brain states to exhibit pre-motor bifurcations toward mutually exclusive decision outcomes. These dynamics arise from a distributed network displaying trial-by-trial functional connectivity changes, especially between cerebellum and habenula, which correlate with decision outcome. Within this network the cerebellum shows particularly strong and predictive pre-motor activity (>10 s before movement initiation), mainly within the granule cells. Turn directions are determined by the difference neuroactivity between the ipsilateral and contralateral hemispheres, while the rate of bi-hemispheric population ramping quantitatively predicts decision time on the trial-by-trial level. Our results highlight a cognitive role of the cerebellum and its importance in motor planning.
|
| 巻・号 |
180(3)
|
| ページ |
536-551.e17
|
| 公開日 |
2020-2-6
|
| DOI |
10.1016/j.cell.2019.12.018
|
| PII |
S0092-8674(19)31380-7
|
| PMID |
31955849
|
| PMC |
PMC7299501
|
| MeSH |
Animals
Behavior, Animal / physiology
Brain Mapping / methods
Cerebellum / physiology*
Cerebrum / physiology
Cognition / physiology
Conditioning, Operant / physiology
Decision Making / physiology*
Goals
Habenula / physiology
Hot Temperature
Larva / physiology
Motor Activity / physiology
Movement
Neurons / physiology
Psychomotor Performance / physiology
Reaction Time / physiology*
Rhombencephalon / physiology
Zebrafish / physiology*
|
| IF |
38.637
|
| リソース情報 |
| ゼブラフィッシュ |
Tg(gad1b:|R|-GFP), gSA2AzGFF152B |
