論文 - 詳細
| RRC ID | 65943 |
|---|---|
| 著者 | Takashima Y, Kawaguchi A, Fukai J, Iwadate Y, Kajiwara K, Hondoh H, Yamanaka R. |
| タイトル | Survival prediction based on the gene expression associated with cancer morphology and microenvironment in primary central nervous system lymphoma. |
| ジャーナル | PLoS One |
| Abstract |
Dysregulation of cell morphology and cell-cell interaction results in cancer cell growth, migration, invasion, and metastasis. Besides, a balance between the extracellular matrix (ECM) and matrix metalloprotease (MMP) is required for cancer cell morphology and angiogenesis. Here, we determined gene signatures associated with the morphology and microenvironment of primary central nervous system lymphoma (PCNSL) to enable prognosis prediction. Next-generation sequencing (NGS) on 31 PCNSL samples revealed gene signatures as follows: ACTA2, ACTR10, CAPG, CORO1C, KRT17, and PALLD in cytoskeleton, CDH5, CLSTN1, ITGA10, ITGAX, ITGB7, ITGA8, FAT4, ITGAE, CDH10, ITGAM, ITGB6, and CDH18 in adhesion, COL8A2, FBN1, LAMB3, and LAMA2 in ECM, ADAM22, ADAM28, MMP11, and MMP24 in MMP. Prognosis prediction formulas with the gene expression values and the Cox regression model clearly divided survival curves of the subgroups in each status. Furthermore, collagen genes contributed to gene network formation in glasso, suggesting that the ECM balance controls the PCNSL microenvironment. Finally, the comprehensive balance of morphology and microenvironment enabled prognosis prediction by a combinatorial expression of 8 representative genes, including KRT17, CDH10, CDH18, COL8A2, ADAM22, ADAM28, MMP11, and MMP24. Besides, these genes could also diagnose PCNSL cell types with MTX resistances in vitro. These results would not only facilitate the understanding of biology of PCNSL but also consider targeting pathways for anti-cancer treatment in personalized precision medicine in PCNSL. |
| 巻・号 | 16(6) |
| ページ | e0251272 |
| 公開日 | 2021-1-1 |
| DOI | 10.1371/journal.pone.0251272 |
| PII | PONE-D-21-02648 |
| PMID | 34166375 |
| PMC | PMC8224980 |
| MeSH | Biomarkers, Tumor / genetics* Central Nervous System Neoplasms / genetics Central Nervous System Neoplasms / mortality* Central Nervous System Neoplasms / pathology Gene Expression Profiling Gene Expression Regulation, Neoplastic High-Throughput Nucleotide Sequencing Humans Lymphoma, Non-Hodgkin / genetics Lymphoma, Non-Hodgkin / mortality* Lymphoma, Non-Hodgkin / pathology Prognosis Survival Rate Tumor Cells, Cultured Tumor Microenvironment* |
| IF | 2.74 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HKBML(RCB0820) |