論文 - 詳細
| RRC ID | 6603 |
|---|---|
| 著者 | Akiyama M, Okano K, Fukada Y, Okano T. |
| タイトル | Macrophage inhibitory cytokine MIC-1 is upregulated by short-wavelength light in cultured normal human dermal fibroblasts. |
| ジャーナル | FEBS Lett |
| Abstract |
To better understand dermal response to visible light, we used DNA microarray analysis to search genes induced by blue or near-UV light in normal human dermal fibroblasts. Of about 12800 transcripts analyzed, near-UV light most prominently upregulated the transcript level of Mic-1, a gene encoding a TGF-beta superfamily protein. Quantitative RT-PCR and immunoblot analyses revealed that mRNA and protein levels of Mic-1 were upregulated by both short-wavelength light but not by green or red light. These results suggest that the human dermis is a site for macrophage inhibitory cytokine-1 (MIC-1) production and that visible light activates a dermal transcription cascade. Considering the role of MIC-1 in immune regulation and appetite control, photic MIC-1 regulation is of physiological importance. |
| 巻・号 | 583(5) |
| ページ | 933-7 |
| 公開日 | 2009-3-4 |
| DOI | 10.1016/j.febslet.2009.02.006 |
| PII | S0014-5793(09)00104-5 |
| PMID | 19302795 |
| MeSH | Cell Line Cycloheximide / pharmacology DNA, Complementary / genetics Fibroblasts Growth Differentiation Factor 15 / genetics Growth Differentiation Factor 15 / metabolism* Health* Humans Light* Oligonucleotide Array Sequence Analysis RNA, Messenger / genetics Skin / drug effects Skin / metabolism* Skin / radiation effects* Up-Regulation / drug effects Up-Regulation / radiation effects* |
| IF | 3.057 |
| 引用数 | 12 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | NB1RGB(RCB0222) |